Markus Muschen, M.D., Ph.D., CLIP InvestigatorCity of Hope National Medical Center

For many patients, CAR T immunotherapies represent a new treatment option when no other therapy was available, so hopefully we can make them more powerful and safer.
Area of Research: Leukemia, Lymphoma, Multiple Myeloma

B cell receptor (BCR) signaling is important for B cell survival, but if the activity is too high or too low, the B cells die. In leukemia and lymphoma, mutations can help cancerous B cells maintain this BCR signaling activity at just the right level. While most current therapeutic approaches try to decrease this signaling, Dr. Muschen is taking the opposite approach and is trying to increase BCR signaling to eliminate cancer cells. He has already shown that small molecules that target the BCR pathway can do this in leukemia cells taken from patients. Now he’s seeing if these molecules can overcome drug resistance in mice and whether they complement CAR T cell immunotherapies against leukemia. Hopefully, this will help pave the way for improved strategies against these blood cancers. 

Projects and Grants

Targeted hyperactivation of B cell receptor signaling to amplify therapeutic responses to CART19-treatment

City of Hope National Medical Center | Leukemia, Lymphoma, Multiple Myeloma | 2016

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*Immunotherapy results may vary from patient to patient.