Cassian Yee, M.D., SU2C-CRI Cancer Immunology Dream Team InvestigatorThe University of Texas MD Anderson Cancer Center

[Combinations] represent an encouraging strategy to enhance the activity of the adoptively transferred T cells and induce antitumor responses.
Area of Research: Prostate Cancer, Kidney Cancer, Melanoma, Lung Cancer, All Cancers

Dr. Yee, along with James P. Allison, Ph.D., Antoni Ribas, M.D., Ph.D., and Drew M. Pardoll, M.D., Ph.D., is leading the SU2C-CRI Cancer Immunology Translational Research Dream Team, which is performing comprehensive experiments aimed at improving immunotherapy’s ability to improve patient outcomes.

Among the Dream Team’s activities are: systematically assessing the expression of candidate molecules and pathways in the tumor microenvironment before and after checkpoint blockade immunotherapy; using a combination of sequencing techniques to assess checkpoint blockade-induced T-cell responses to tumor-specific neo-antigens; working to improve the quality of cancer-specific T cell generated for adoptive cell transfer (ACT) therapy; evaluating the effect of epigenetic therapy on immunotherapy and assessing the combination of checkpoint blockade immunotherapy and  ACT in patients.

Projects and Grants

Immunologic checkpoint blockade and adoptive cell transfer in cancer therapy

The University of Texas MD Anderson Cancer Center | All Cancers, Kidney Cancer, Lung Cancer, Melanoma, Prostate Cancer | 2013

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