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Chang-Suk Chae, Ph.D., Dr. Keith Landesman Memorial FellowWeill Cornell Medicine

This [CRI postdoctoral fellowship] will support this critical phase of my scientific career and, most importantly, bring hope to ovarian cancer patients.
Area of Research: Ovarian Cancer

Ovarian cancer affects over 20,000 women, and results in approximately 14,000 deaths, each year in the United States. Unfortunately, current immunotherapies have not been very successful for ovarian cancer patients, because these tumors often maintain an immunosuppressive environment that prevents effective anti-tumor immune responses.

To address this, Dr. Chae aims to identify and understand the mechanisms through which tumors achieve this, so that he can disable them. Specifically, he’s characterizing how stress responses in the endoplasmic reticulum inhibit the natural function of dendritic cells (DCs), which are important for coordinating overall immune responses. One pathway in particular interests him, and he’s determining if inhibiting it enhances DC activity and helps improve the effectiveness of current immunotherapies.

Projects and Grants

Incessant ER stress responses promote dendritic cell dysfunction in ovarian cancer

Weill Cornell Medicine | Ovarian Cancer | 2017 | Juan R. Cubillos-Ruiz, Ph.D.

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