University of Pennsylvania School of Medicine
Philadelphia, PA

Dr. E. John Wherry is the director of the Institute for Immunology and a professor in the Department of Microbiology at the University of Pennsylvania School of Medicine. Dr. Wherry’s expertise lies mainly in T cell exhaustion, which can hamper anti-tumor immune responses. He’s helped advance our understanding of how gene expression changes affect this exhaustion, which has led to strategies to improve the effectiveness of T cell-targeting immunotherapies. In recognition of his achievements, Dr. Wherry received the 2016 Frederick W. Alt Award for New Discoveries in Immunology, and is also member of CRI’s Clinical Leadership Committee.

[Our major goal] is to understand the mechanisms of T cell exhaustion during chronic infections and cancer.
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*Immunotherapy results may vary from patient to patient.