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Xiaojun Tan, Ph.D., Postdoctoral FellowThe University of Texas Southwestern Medical Center

Clinical breakthroughs come from basic science. The CRI fellowship provided me the freedom to explore new basics of immunotherapy.
Area of Research: All Cancers

Dying cancer cells often release DNA that can be recognized by the protein STING, which then stimulates interferon (IFN) production and an anti-tumor immune response. However, once STING is activated, how it mediates an immune response is still unclear, so Dr. Tan is investigating how a group of intracellular trafficking proteins regulate STING and anti-cancer responses. Specifically, he’s seeking to identify STING’s binding properties and how that regulates its activity, which could help foster STING-targeting strategies that improve outcomes in patients.

Projects and Grants

Phosphoinositide regulation of STING trafficking and cancer immunity

The University of Texas Southwestern Medical Center | All Cancers | 2016 | Zhijian J. Chen, Ph.D.

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