CRI Funded Scientists

Qianxia Zhang, PhD, Postdoctoral Fellow

Boston Children's Hospital

The mammalian adaptive immune system relies on a series of intricate selection process on immune repertoires to enforce a robust discrimination between self and non-self, which is the key to prevent autoimmunity. However, since self-antigens are shared in tumor tissues, robust self-tolerance can also limit effective anti-tumor immune responses. Therefore, a clear molecular understanding of how the immune system discriminate self and non-self can provide therapeutic guidance for autoimmune disease and cancer immunotherapies. 

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