Immunotherapy works by activating the body’s own immune system to fight cancer, but many patients eventually stop responding because their T cells become “exhausted” and lose their ability to attack tumors effectively.
Dr. Liu studies the molecular signals that control T cell function inside tumors. His previous work at leading research Institution:s in China uncovered important mechanisms regulating immune exhaustion and cancer progression, resulting in publications in major scientific journals including Nature, Cancer Cell, and Nature Immunology.
This project investigates a molecule called Chrna7 (Cholinergic receptor alpha 7), a receptor found on T cells that appears to promote T cell exhaustion. Dr. Liu’s early studies show that mice lacking this receptor develop stronger anti-tumor immune responses and experience slower tumor growth.
Using advanced genetic and molecular approaches, he will determine how Chrna7 weakens T cell function and whether blocking this pathway can restore the ability of T cells to fight cancer. The long-term goal is to identify new therapeutic strategies that keep T cells active longer and improve the effectiveness of immunotherapy. If successful, this work could help overcome one of the major barriers limiting current cancer immunotherapies.
Mentor
Tak W. Mak, PhD
Projects and Grants
Regulation of T cell exhaustion and anti-tumor immunity by Cholinergic receptor alpha 7
