Dr. Wang is investigating how cycles of fasting and refeeding reshape metabolism in ways that strengthen the immune system’s ability to fight cancer. Alternate day fasting (ADF), a practiced regimen known to improve human metabolic health, exhibits anti-tumor activity in preclinical studies. She has identified naturally occurring metabolites such as beta-hydroxybutyrate and succinate that may improve immune cell function or reprogram the tumor microenvironment. Her aim is to better understand the molecular mechanisms that make ADF an effective dietary regiment. In doing so, she hopes to translate these findings into safe metabolic therapies that enhance cancer treatment without the toxicity often associated with drugs.
Dr. Wang’s scientific background spans nutrition, metabolism, and immunology. Earlier in her career, she helped answer a longstanding question in cancer biology related to the Warburg effect, work that was highlighted by Science and MIT Technology Review. She is currently completing her training at John Hopkins under leaders in cancer metabolism and immunotherapy.
Mentors
Chi Dang, MD, PhD, Drew Pardoll, MD, PhD
Projects and Grants
Fasting–refeeding cycles enhance anti-tumor immunity
