Skip to main content
Let's spread the word about Immunotherapy! Click to share this page with your community.

ASCO17: Day 2 Immunotherapy Highlights

June 04, 2017

Day 2 at the 2017 annual meeting of the American Society of Clinical Oncology further highlighted immunotherapy's potential to treat many of the most common types of cancer. Here is an overview of the data coming out of today's session:

Multiple Tumor Types:

Bladder Cancer:

  • In a phase I/II clinical trial, the amount of circulating tumor DNA in the blood soon after treatment with durvalumab (anti-PD-L1 checkpoint immunotherapy) decreased in patients who responded, and was associated with increased survival (both overall and progression-free survival). http://abstracts.asco.org/199/AbstView_199_184983.html

Brain Cancer:

Breast Cancer:

  • In a phase II clinical trial, pembrolizumab (anti-PD-1 checkpoint immunotherapy) led to durable responses in some heavily pre-treated patients with metastatic triple-negative breast cancer (TNBC). http://abstracts.asco.org/199/AbstView_199_190305.html
  • In a phase III clinical trial, the immunotherapy trastuzumab emtansine (anti-HER antibody with a toxin attached) was shown to be an effective first-line treatment for patients with HER2+ metastatic breast cancer, and exhibited fewer severe adverse events and an increased median overall survival compared to the standard trastuzumab (anti-HER2 antibody immunotherapy) plus chemotherapy regimen. http://abstracts.asco.org/199/AbstView_199_185945.html
  • In a phase II clinical trial, the combination of pembrolizumab (anti-PD-1 checkpoint immunotherapy) and chemotherapy was able to stimulate immune responses that led to clinical benefits in multiple patients with metastatic triple-negative breast cancer (TNBC). http://abstracts.asco.org/199/AbstView_199_194049.html   

Cervical Cancer:

Childhood Cancer:

Colorectal Cancer:

  • In a phase II clinical trial, the combination of pembrolizumab (anti-PD-1 checkpoint immunotherapy) and chemotherapy demonstrated promise as a first-line treatment for patients with advanced colorectal cancer, even for patients whose tumors were DNA mismatch repair proficient (pMMR). http://abstracts.asco.org/199/AbstView_199_183499.html
  • In a phase II clinical trial, dual checkpoint immunotherapy with nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4) led to high rates of response and disease control in patients with MSI-hi / DNA mismatch repair deficient (dMMR) colorectal cancer. http://abstracts.asco.org/199/AbstView_199_185252.html

Esophageal Cancer:

  • In a phase I clinical trial, the combination of pembrolizumab (anti-PD-1 checkpoint immunotherapy) and ramucirumab (anti-VEGFR2 antibody immunotherapy) showed promise in patients with gastroesophageal junction adenocarcinoma, both as a first-line treatment and after previous treatment with other therapies. http://abstracts.asco.org/199/AbstView_199_184481.html
  • The presence of microsatellite instability (MSI) or high mutational load (>10 mutations / million base pairs) in the tumors of esophagogastric cancer patients were much more likely to benefit from immunotherapy (either anti-PD-1/PD-L1 checkpoint immunotherapy, or combined anti-PD-1/PD-L1 + anti-CTLA-4 checkpoint immunotherapy). http://abstracts.asco.org/199/AbstView_199_191437.html

Leukemia:

Liver Cancer:

Lung Cancer:

  • In a phase I clinical trial, first-line treatment with the checkpoint immunotherapy combination of nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4) was effective for patients with advanced non-small cell lung carcinoma (NSCLC), resulting in six complete responses. Patients whose tumors expressed high levels of PD-L1 were more likely to benefit, but even some patients with minimal PD-L1 expression experienced complete responses. (This work involved Scott J. Antonia, M.D., Ph.D., and Julie R. Brahmer, M.D.) http://abstracts.asco.org/199/AbstView_199_184051.html
  • In a phase I/II clinical trial, the checkpoint immunotherapy combination of epacadostat (anti-IDO1) and pembrolizumab (anti-PD-1) provided benefits for patients with non-small cell lung carcinoma (NSCLC). http://abstracts.asco.org/199/AbstView_199_181148.html
  • In a phase I clinical trial, the combination of AM0010 (PEGylated IL-10 cytokine immunotherapy) and pembrolizumab (anti-PD-1 checkpoint immunotherapy) was effective at activating killer T cells and demonstrated clinical activity in patients with advanced non-small cell lung carcinoma (NSCLC). http://abstracts.asco.org/199/AbstView_199_189952.html
  • In a phase II clinical trial, pembrolizumab (anti-PD-1 checkpoint immunotherapy) led to a 21% response rate and an 80% disease control rate in patients with mesothelioma, regardless of PD-L1 expression. http://abstracts.asco.org/199/AbstView_199_191066.html

Melanoma:

Multiple Myeloma:

  • Patients with active multiple myeloma were found to have a higher proportion of regulatory T cells with high expression of checkpoint receptors, and the addition of checkpoint immunotherapies (either anti-PD-1, anti-LAG3, or anti-TIM3) were able to promote myeloma-specific anti-tumor activity in these cells. http://abstracts.asco.org/199/AbstView_199_190626.html

Ovarian Cancer:

  • In a phase II clinical trial, patients whose tumors were highly mutated and expressed higher levels of PD-L1 appeared more likely to respond to pembrolizumab (anti-PD-1 checkpoint immunotherapy). http://abstracts.asco.org/199/AbstView_199_186033.html
  • In a phase II clinical trial, vaccination with oregovomab (anti-CA125 antibody immunotherapy) along with chemotherapy was able to enhance anti-tumor immune activity and patient outcomes compared to chemotherapy alone in patients with stage III/IV ovarian cancer. http://abstracts.asco.org/199/AbstView_199_184570.html
  • In a phase I clinical trial, mirvetuximab soravtansine (an antibody-drug conjugate immunotherapy that targets the folate receptor alpha) demonstrated increased clinical benefits compared to chemotherapy for patients with platinum-resistant ovarian cancer. http://abstracts.asco.org/199/AbstView_199_190120.html

Pancreatic Cancer:

  • In a phase I clinical trial, MVT-5873 (anti-CA19-9 antibody immunotherapy) was able to reduce serum levels of CA19-9 and showed signs of effectiveness in patients with CA19-9+ pancreatic cancer. http://abstracts.asco.org/199/AbstView_199_190708.html
  • In a phase I clinical trial, the combination of TG01 (anti-RAS peptide vaccine), GM-CSF (an immunomodulator), and chemotherapy stimulated immune responses in 84% of patients with RAS-mutated pancreatic cancer when the combination was givne after surgery. http://abstracts.asco.org/199/AbstView_199_191964.html

Sarcoma:

Stomach & Gastrointestinal Cancer:

  • The combination of pembrolizumab (anti-PD-1 checkpoint immunotherapy) and ramucirumab (anti-VEGFR2 antibody immunotherapy) showed promise in patients with gastric adenocarcinoma, both as a first-line treatment and after previous treatment with other therapies. http://abstracts.asco.org/199/AbstView_199_184481.html
  • The presence of microsatellite instability (MSI) or high mutational load (>10 mutations / million base pairs) in the tumors of esophagogastric cancer patients were much more likely to benefit from immunotherapy (either anti-PD-1/PD-L1 checkpoint immunotherapy, or combined anti-PD-1/PD-L1 + anti-CTLA-4 checkpoint immunotherapy). http://abstracts.asco.org/199/AbstView_199_191437.html

Come back for more updates from tomorrow's presentations.

Be in the know with the latest immunotherapy news

*Immunotherapy results may vary from patient to patient.

Top