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Landscape of Immuno-Oncology Drug Development

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With an unprecedented number of new investigational agents and companies in immuno-oncology (IO), it has been difficult to track and understand the current IO agents in clinical development and the clinical trials testing these agents. The Clinical Accelerator team presents an unbiased, neutral, scientifically curated, and timely updated analysis based on information collected from numerous trusted and publicly available sources.

We hope to inform the cancer research community through academic publications as it strives for efficiencies and innovation while avoiding duplication. As of today, we have four landscape publications:

Additionally, data from our Immuno-Oncology Landscape has been featured in a review of IO combination trials in breast cancer:

  • Immunotherapy and targeted therapy combinations in metastatic breast cancer (The Lancet, Oncology, March 2019)

A comparison of global IO pipelines in 2017 and 2018. 3,394 immuno-oncology agents in six main classes were identified in September 2018, an increase of 67% since the previous survey. More details can be found in the Nature Reviews Drug Discovery article.

A global landscape of cancer cell therapies. 753 cancer cell therapies are included in the interactive dashboard. The top graph serves as the filter to curate the following two graphs and one table. Seven different classes of cell therapies are defined based on their mechanism of actions. More details and other analyses can be found in the Nature Reviews Drug Discovery article.

Timeline of Anti-PD-1/L1 Antibody Approvals by the FDA

Timeline of non-PD-1/PD-L1 Immuno-Oncology Agent Approvals by the FDA

Data Sources: Cancer Research Institute (CRI) analytics derive from public data sources, including trade news, company press releases, academic publications, FDA announcements, clinicaltrials.gov, and conference reports, and proprietary data sources including, but not limited to, GlobalData. The analytical algorithm and visualizations are developed by and therefore sole property of Cancer Research Institute.

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*Immunotherapy results may vary from patient to patient.

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