Oncolytic Virus Therapy

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  • Oncolytic Virus Therapy
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Oncolytic Virus Therapy: How Oncolytic Virus Therapy is Changing Cancer Treatment

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Oncolytic viruses are a form of immunotherapy that uses viruses to infect and destroy cancer cells.

Viruses infect our cells and insert their genes into our chromosomes, leading to the production of new copies of the virus that then infect other cells. Infection by certain viruses has been implicated in the development of certain cancers, such as the hepatitis B virus (HBV) in liver cancer and the human papilloma virus (HPV) in cervical cancer and head and neck cancer. (In the case of HPV and hepatitis, another type of immunotherapy—<<<vaccines>>>HYPERLINK TO COME—has shown the ability to prevent infection and protect against the formation of these HPV- and HBV-related cancers.)

More recently, modified versions of viruses have been designed to target and attack tumors that have already formed. These are known as oncolytic viruses and they represent a promising approach to treating cancer for several reasons:

  1. Cancer cells often have impaired defenses that make them susceptible to infection.
  2. These viruses can be modified from their natural form to give them advantageous properties, including decreasing their ability to infect healthy cells as well as granting them the ability to produce immune-boosting molecules once they infect tumor cells.
  3. After infection, these oncolytic viruses can cause cancer cells to “burst”—killing the cancer cells and releasing cancer antigens. These antigens can then stimulate immune responses that can seek out and eliminate any remaining tumor cells nearby and potentially anywhere else in the body.

In 2015, the U.S. Food and Drug Administration (FDA) approved the first oncolytic virus immunotherapy for the treatment of cancer—T-VEC for melanoma. This oncolytic vaccine involves a herpes virus that has been engineered to be less likely to infect healthy cells. It has also been engineering to cause infected cancer cells to produce the immune-stimulating GM-CSF protein.

Oncolytic Virus Therapy Treatment Options

There is currently one FDA-approved oncolytic virus therapy approved by the FDA for the treatment of cancer:

  • T-VEC (Imlygic®): a modified herpes simplex virus (HSV) that infects tumor cells and promotes their destruction; approved for subsets of patients with melanoma

Side Effects

Side effects can vary according to the type of oncolytic virus—and what exactly it targets—and can also be influenced by the location and type of cancer as well as a patient’s overall health. Due to their potential to infect healthy cells as well as stimulate overall immune activity, sometimes oncolytic viruses can cause the immune system to attack healthy cells and carry the risk of infection. Patients should always consult their doctors and the rest of their care team to gain a better and fuller understanding of the potential risks and side effects associated with specific oncolytic viruses.

The side effects most commonly associated with the currently approved oncolytic virus are: chills, fatigue, flu-like symptoms, injection site pain, nausea, and pyrexia. For information regarding the side effects associated with oncolytic viruses and other immunotherapy approaches, please refer to our Immunotherapy Side Effects page.

CRI’s Impact in Oncolytic Virus Therapy

Throughout CRI’s history, we have supported a variety of basic research aimed at improving our understanding of the how viruses interact with our cells and immune system as well as translational and clinical efforts that seek to use these insights in the development of oncolytic virus therapies for cancer patients in the clinic.

Some of the most important contributions made by CRI scientists in the area of oncolytic viruses include:

  • In 2018, CRI CLIP investigator John C. Bell, Ph.D., of the Ottawa Hospital Research Institute, revealed that treating triple-negative breast cancer patients with oncolytic virus therapy prior to surgery increased their likelihood of responding to checkpoint immunotherapy.

Additionally, CRI is currently providing funding support for the following clinical trial involving oncolytic virus therapy:

  • A phase I/II trial (NCT02963831) combining an oncolytic virus and a checkpoint inhibitor in patients with advanced appendiceal cancer, colorectal cancer, and ovarian cancer. This trial is being led by and Kunle Odunsi, M.D., Ph.D., of the Roswell Park Comprehensive Cancer Center, and Dmitriy Zamarin, M.D., Ph.D., of Memorial Sloan Kettering Cancer Center.
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Oncolytic Virus Clinical Trial Platforms

Oncolytic virus platforms under evaluation in clinical trials include:

  • Adenovirus: a family of common viruses that can cause a wide range of typically mild effects including sore throat, fatigue, and cold-like symptoms
  • Coxsackievirus: a virus that belongs to the same group as the polio virus; commonly infects young children and causes flu-like symptoms
  • Herpes simplex virus: a virus that can cause the formation of sores on the mouth and genitals
  • Maraba virus: a virus found exclusively in insects
  • Measles: a highly contagious virus that infects the respiratory tract and can cause measles
  • New Castle Virus: a virus primarily found in birds; can cause mild conjunctivitis and flu-like symptoms in humans
  • Picornavirus: a family of viruses that can cause a range of diseases in mammals and birds
  • Reovirus: a family of viruses that can affect the gastrointestinal and respiratory tracts in a range of animal species
  • Vaccinia virus: the virus that was used to help vaccinate against and eliminate smallpox; rarely causes illness in humans and is associated with a rash covering the body
  • Vesicular stomatitis virus: a virus that belongs to the same family as the rabies virus; can cause flu-like symptoms in humans

In addition to these oncolytic virus platforms currently being evaluated, new platforms and approaches are constantly being developed and investigated in clinical trials. To determine if you or someone you know might be eligible for an immunotherapy clinical trial, please consult our Clinical Trial Finder service.

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Sources: CRI documents; U.S. Food and Drug Administration (FDA); FDA Hematology/Oncology (Cancer) Approvals & Safety Notifications; FDA Online Label Repository

Updated April 2019

*Immunotherapy results may vary from patient to patient. Consult a health care professional about your treatment options.

*Immunotherapy results may vary from patient to patient.