CRI Clinical Innovator

The Clinical Innovator provides funding for clinician-scientists aiming to launch innovative phase I/II or phase II clinical studies using novel immunotherapies. In addition to the merits of the clinical and scientific rationale, studies will be selected based on their novelty, feasibility, and clinical impact. Competitive applications will have a strong focus on yielding mechanistic insights into clinical response and potentials for biomarker discovery and/or validation. CRI will coordinate efforts on selected trials by advising on the following areas: standardizing sample collection, correlative assays, analysis, and data sharing, including, if applicable, deposition of immunogenomic data into the CRI iATLAS platform. 

The Clinical Innovator will provide up to USD $1 million for each clinical trial it supports. The funds may be used for salary, supplies, patient costs, correlative assays, and data analyses. Payment will be structured into milestones to ensure that studies will advance and be brought to completion. 

The deadline to submit an Initial Protocol Concept is December 1. Candidates will be notified by late February if they are invited to submit a full proposal, including protocol. Invited applications are due May 1. If these deadlines fall on the weekend, proposals will be accepted until the close of business that following Monday.

Candidates must be the Principal Investigator (PI) of the proposed study. CRI has no citizenship restrictions, and research supported by the award may be conducted at medical schools or research centers in the United States or abroad. Please note that CRI does not support research at for-profit institutions.

An initial Protocol Concept must be submitted electronically using the CRI online submission portal. If this is the first time you are submitting a grant application to CRI, you will be asked to create a new user account to catalog all applications you submit to CRI.

The Initial Protocol Concept must include:  

1. PDF Cover Sheet (1 page)
2. A brief protocol concept (maximum 2 pages, excluding study schema and references) including;
   a. Study rationale
   b. Primary objectives 
   c. Secondary objectives
   d. Number of patients to be treated
   e. Patient eligibility criteria
   f. Sample collection plan
   g. Biostatistics plan
3. A separate one-page study schema should be uploaded outlining the clinical design.
4. A brief translational plan (maximum 1 page, excluding references)
   a. Translational aims and rationale 
   b. Assays intended to use and samples to be tested
5. Biographical sketches for PI(s) and co-PI(s) (limit bibliography to past 5 years or publications relevant to proposed study)

Notes:

• Only PDF documents will be accepted. All files must be submitted individually on the attachments page of the online application.
• When you have finished uploading the attachments, click “Submit.” You will receive a notice confirming that you have successfully submitted your Application Form. Immediately after, an automated notification from CRI will be sent to your email address, also confirming submission. If you encounter problems uploading your attachments, email them to [email protected]. Be sure to note the application number, which will be assigned to you at the time of submission.
• Online applications will be accepted until 5 p.m. Eastern Time on the deadline date. If the deadline falls on the weekend, applications will be accepted until the close of business that following Monday. We strongly suggest submitting your applications as early as possible to provide ample time in case your application is incomplete. Incomplete applications will not be considered.
• Formatting Guidelines: Any documents you attach to your online application form must be typed single-space using a 12 point or larger font size.

All awardees must adhere to the terms of this award.

Please note: The Cancer Research Institute will not modify the terms of its policies at the request of individual institutions. Policies have been approved by our Board of Trustees, and we do not have the resources to negotiate separately with the many institutions that receive our support.