Glioblastoma is the most lethal form of brain cancer in adults. Due to the ineffectiveness of current treatments, Dr. Peiwen Chen’s goal is to figure out how immune cells might be more effectively employed in targeting and eliminating brain cancer cells. Specifically, Dr. Chen aims to identify which genetic events in the cancer cells drive immune responses in glioblastoma, and to determine which immune cells are affected in this process. By characterizing the mechanisms that underlie this communication between cancer cells and immune cells in the tumor environment as well as the roles that individual genes play in this behavior, Dr. Chen hopes to uncover insights that can be used to develop novel immunotherapy strategies against this feedback loop and improve outcomes for these patients with glioblastoma.
The University of Texas MD Anderson Cancer Center | Brain Cancer | 2018 | Ronald A. DePinho, M.D.
*Immunotherapy results may vary from patient to patient.
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CRI scientists Dr. Michele Ardolino and Dr. David Raulet showed that Natural Killer cells can help eliminate tumors after checkpoint immunotherapy treatment even in the absence of T cells.
The third installment of the Rational Combinations 360 conference, which will be held in Philadelphia September 13-14, seeks to improve the design and application of combination immunotherapies for patients