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Pawel Kalinski, M.D., Ph.D., Clinical Team LeaderRoswell Park Cancer Institute

The research of my group aims to determine the cellular and molecular background of the interactions between tumors and the immune system.
Area of Research: Brain Cancer, Colorectal Cancer, Prostate Cancer, All Cancers

Dr. Kalinski, along with Hideho Okada, M.D., Ph.D., Lawrence Fong, M.D., and Kunle Odunsi, M.D., Ph.D., is focusing on timely development of innovative clinical strategies to improve the ability of T cells to infiltrate and eliminate tumors. Although technologies are available for systemic infusion of large numbers of anti-cancer T cells and reversal of local immune suppression for solid cancers including brain, colorectal, ovarian and prostate, a major unsolved challenge is to drive sufficient number of T cells to the tumor site. To address this, Dr. Kalinski and his colleagues are testing a triple combination called CKM―of IFN-α, TLR3 ligands (PolyI:PolyC12U/rintatolimod or Poly-ICLC) and celecoxib―in preclinical cancer models as well as in phase I and II clinical trials. They're also evaluating how the CKM regimen combines with vaccines and checkpoint immunotherapy.

Projects and Grants

Enhancing T-cell homing to solid cancers by stimulating proper chemokines

University of Pittsburgh School of Medicine | All Cancers, Brain Cancer, Colorectal Cancer, Ovarian Cancer, Prostate Cancer | 2015

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