Radiation therapy can cause significant toxicity in patients. Lower doses help limit this damage, but can also decrease the treatment’s effectiveness. Dr. Olcina is exploring how we might address these toxicities without compromising the treatment itself. Radiotherapy works in part by stimulating an adaptive immune response against cancer, which benefits patients. But it may also activate an innate immune response through the complement pathway that can promote tissue-damaging inflammation. To determine how we might prevent this, she’s characterizing how different doses of radiation activate the complement pathway and how it affects other immune cells, with the goal of identifying ways that immunotherapy might be able to boost radiotherapy’s benefits while reducing its drawbacks.
Stanford University | Bladder Cancer, Colorectal Cancer, Esophageal Cancer | 2016 | Amato J. Giaccia, Ph.D.
*Immunotherapy results may vary from patient to patient.
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Kate Bockholt (Our Cause) makes jewelry and donates her proceeds to nonprofit organizations, including the Cancer Research Institute.
This July for Sarcoma Awareness Month, we look at genetics and genomics, new research, and how we’re working toward a future immune to sarcoma.