Some tumors maintain environments that suppress anti-cancer T cells and protect them against checkpoint inhibitor immunotherapies. To help devise ways to overcome this resistance, Dr. Curran is investigating the role that low oxygen conditions―known as hypoxia―play in preventing effective immune responses in these hard-to-treat cancers, including prostate cancer. He’s characterizing how hypoxia affects the activity of both anti-cancer T cells and pro-cancer immune cells, as well as how disrupting this hypoxia affects the immune system’s ability to eliminate cancer, both alone and in combination with checkpoint inhibitors. These insights should provide a promising path forward for identifying and developing immunotherapy approaches for prostate tumors and other tough-to-treat cancers.
The University of Texas MD Anderson Cancer Center | All Cancers, Pancreatic Cancer, Prostate Cancer | 2016
*Immunotherapy results may vary from patient to patient.
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A recent diabetes-related discovery by CRI Lloyd J. Old STAR Dr. Andrea Schietinger has promising implications for cancer immunotherapy
Rare and ultra-rare cancers affect around 20,000 people in the United States alone, according to Foundation Medicine, Inc. Immunotherapy research in some of the more common cancers and the identification of biomarkers that can predict patient responses is opening this new approach to cancer treatment up to patients whose cancers currently receive little direct attention.