Jun P. Hong, Ph.D., Postdoctoral Fellow The Rockefeller University

My project seeks to provide the mechanism of our immune defense system so that we may be able to utilize the knowledge to design effective vaccine regimen against important infectious diseases.
Area of Research: All Cancers

After a natural infection or a vaccine, B cells within germinal centers (specialized anatomical structures) divide, mutate their antibody genes, and mature—ultimately producing antibodies to protect us. While these behaviors are beneficial for immune responses, they can also increase the risk of developing B cell lymphomas.

Dr. Hong is studying the mechanisms that determine B cell fate, in order to shed light on why cancers develop as well as what factors cause B cells to acquire long-lasting memory. These insights could then reveal how to manipulate B cell behavior, against cancer as well as other diseases through the design of superior vaccine strategies.

Projects and Grants

Defining the Mechanisms That Govern B Cell Fate Decisions in the Germinal Center and Establishing Molecular Inputs That Regulate B Cell Memory

The Rockefeller University | All Cancers | 2021 | Michel Nussenzweig, M.D., Ph.D.

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