{"id":26299,"date":"2017-03-16T16:41:00","date_gmt":"2017-03-16T20:41:00","guid":{"rendered":"https:\/\/www.cancerresearch.org\/blog\/marzo-2017\/therese-b"},"modified":"2022-10-14T19:30:21","modified_gmt":"2022-10-14T23:30:21","slug":"therese-b","status":"publish","type":"post","link":"https:\/\/www.cancerresearch.org\/es\/blog\/therese-b","title":{"rendered":"Th\u00e8r\u00e9se B’s Immunotherapy Story"},"content":{"rendered":"\n

Melanoma<\/strong><\/p>\n\n\n\n

Me sorprende estar con vida porque s\u00e9 lo terrible que es esta enfermedad.<\/p><\/blockquote>\n\n\n\n

La historia de Th\u00e8r\u00e9se<\/h2>\n\n\n\n

Como m\u00e9dica y anatomopat\u00f3loga, Th\u00e8r\u00e9se Bocklage sab\u00eda que su pron\u00f3stico era desalentador. El melanoma que le hab\u00edan extirpado 20 a\u00f1os antes hab\u00eda regresado y se hab\u00eda diseminado a los pulmones y el abdomen. Pero tambi\u00e9n sab\u00eda que todos los d\u00edas hay nuevos tratamientos disponibles para su tipo de c\u00e1ncer y ten\u00eda colegas especialistas a quienes pedir orientaci\u00f3n.

Esa orientaci\u00f3n la condujo al Dr. Antoni Ribas, Ph. D.<\/a>, onc\u00f3logo del Jonsson Comprehensive Cancer Center de la UCLA, promotor de nuevos tratamientos para el melanoma. El que Th\u00e8r\u00e9se recibi\u00f3 es un novedoso medicamento denominado pembrolizumab<\/a>, fabricado por Merck. Se trata de un anticuerpo dirigido a la mol\u00e9cula PD-1 de los linfocitos T. La prote\u00edna PD-1 es un punto de control que suprime las respuestas inmunitarias. Al bloquearla, el pembrolizumab \u00absuelta los frenos\u00bb de la respuesta inmunitaria y permite que combata el c\u00e1ncer de manera m\u00e1s potente.

La Dra. Bocklage comenz\u00f3 el tratamiento en enero de 2012. Un poco m\u00e1s de 2 a\u00f1os despu\u00e9s, TheAnswertoCancer (TheA2C) convers\u00f3 con esta m\u00e9dica cient\u00edfica de 54 a\u00f1os, que est\u00e1 en remisi\u00f3n completa.<\/p>\n\n\n\n

Preguntas y respuestas<\/h2>\n\n\n\n\n

Bueno, tenemos que remontarnos a 1991. Estaba con unos amigos, que eran compa\u00f1eros m\u00e9dicos residentes, haciendo senderismo en la Sierra de Sand\u00eda. Uno de mis amigos que caminaba detr\u00e1s de m\u00ed se dio cuenta de que ten\u00eda un lunar de aspecto raro en la parte posterior de la pierna. Eso fue cuando ten\u00eda 31 a\u00f1os. Result\u00f3 ser un melanoma muy peque\u00f1o y m\u00ednimamente invasivo que hab\u00eda surgido de un lunar que tuve toda la vida. Me lo quitaron a fines de 1991. Era poco profundo y no hab\u00eda indicios de propagaci\u00f3n, y el 98 % de las personas se curan con ese grado de invasi\u00f3n. <\/p>\n\n\n\n

Pero, a fines de 2011, cuando estaba entrando a la casa un \u00e1rbol de Navidad de la cochera, me golpe\u00e9 la pierna. Despu\u00e9s de eso not\u00e9 un bulto y pens\u00e9 que tal vez era por el \u00e1rbol de Navidad. Sin embargo, no desapareci\u00f3 y no ten\u00eda ning\u00fan hematoma. Me acerqu\u00e9 a una amiga que estaba en la casa, que es histopat\u00f3loga, y le dije: \u00ab\u00bfCrees que me deber\u00edan revisar esto?\u00bb Me respondi\u00f3 que s\u00ed. As\u00ed que de inmediato me hizo una biopsia por aspiraci\u00f3n con aguja fina y result\u00f3 ser un melanoma metast\u00e1sico. Esa es una de las cosas m\u00e1s extra\u00f1as del melanoma, que puede aparecer muchos a\u00f1os despu\u00e9s, y as\u00ed fue. <\/p>\n\n\n\n\n\n

En el sitio web del Instituto Nacional del C\u00e1ncer hay muchos ensayos cl\u00ednicos en los que uno puede intentar inscribirse. As\u00ed que le pregunt\u00e9 a mi amiga, que es especialista en melanoma, qu\u00e9 pensaba y me habl\u00f3 muy bien de Toni Ribas. Y resulta que Toni Ribas est\u00e1 en UCLA, que queda a 5 km de donde viven mi hermana y su esposo, as\u00ed que pod\u00eda quedarme con ellos cuando fuera a hacerme el tratamiento. <\/p>\n\n\n\n

Era un anticuerpo dirigido a PD-1. La PD-1 es la prote\u00edna de los linfocitos T que act\u00faa como \u00abfreno\u00bb de la respuesta inmunitaria. Las c\u00e9lulas tumorales malignas activan ese freno en los linfocitos T, lo que les impide entrar y atacar el tumor. Entonces, el anticuerpo se pega a esa prote\u00edna y como que suelta los linfocitos T para que puedan entrar y atacar el melanoma. <\/p>\n\n\n\n

Comenc\u00e9 en enero de 2012 y termin\u00e9 en diciembre de 2013. Fui menos de dos a\u00f1os. Me sent\u00eda muy bien y el Dr. Ribas pens\u00f3 que me estaba yendo muy bien. Present\u00e9 remisi\u00f3n completa a los 6 meses del tratamiento, por lo que no tuve que seguir hasta completar los dos a\u00f1os. <\/p>\n\n\n\n\n\n

El \u00fanico efecto secundario que tuve fue un poco de cansancio; aparte de eso, nada. Cada dos semanas iba a la UCLA y me hac\u00edan algunos an\u00e1lisis de sangre. La infusi\u00f3n en s\u00ed era muy sencilla y duraba solo 30 minutos.<\/p>\n\n\n\n

Durante la infusi\u00f3n, estaba en la gran sala con todos los dem\u00e1s pacientes de c\u00e1ncer. Muchos eran pacientes con c\u00e1ncer de mama, pacientes con c\u00e1ncer de pr\u00f3stata que recib\u00edan m\u00faltiples medicamentos durante 6 u 8 horas y ten\u00edan n\u00e1useas. Me sent\u00eda muy apenada por ellos porque yo entraba y sal\u00eda en media hora. <\/p>\n\n\n\n

Las enfermeras fueron simplemente extraordinarias, muy amables, es excelente el personal de enfermer\u00eda oncol\u00f3gica. As\u00ed que fue un proceso pr\u00e1cticamente indoloro.<\/p>\n\n\n\n\n\n

A los pacientes con melanoma avanzado les recomendar\u00eda que no se rindan y que sean conscientes de que estamos teniendo tratamientos nuevos y extraordinarios. No hay que darse por vencidos. Hay que actuar junto con otras personas, hablar con otros pacientes, ingresar a los sitios web donde la gente indica con qui\u00e9nes han trabajado, hablar con los m\u00e9dicos. Pero no hay que rendirse, porque se est\u00e1n probando nuevos tratamientos que est\u00e1n demostrando ser muy eficaces.\u00a0<\/p>\n\n","protected":false},"excerpt":{"rendered":"

Melanoma Me sorprende estar con vida porque s\u00e9 lo terrible que es esta enfermedad. La historia de Th\u00e8r\u00e9se Como m\u00e9dica y anatomopat\u00f3loga, Th\u00e8r\u00e9se Bocklage sab\u00eda que su pron\u00f3stico era desalentador. El melanoma […]<\/p>\n","protected":false},"author":22,"featured_media":21912,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[678],"tags":[409,439],"resource_cancer_types":[],"resource_patient_age":[],"resource_cancer_stage":[],"resource_treatment_type":[],"resource_treatment_status":[],"class_list":["post-26299","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-patient-story-es","tag-melanoma-es","tag-patient-stories-es"],"acf":[],"yoast_head":"\nTh\u00e8r\u00e9se B's Immunotherapy Story - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/blog\/therese-b\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Th\u00e8r\u00e9se B's Immunotherapy Story - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"Melanoma Me sorprende estar con vida porque s\u00e9 lo terrible que es esta enfermedad. 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