{"id":26054,"date":"2017-03-15T15:39:00","date_gmt":"2017-03-15T19:39:00","guid":{"rendered":"https:\/\/www.cancerresearch.org\/blog\/marzo-2017\/dave-h"},"modified":"2022-10-13T08:59:05","modified_gmt":"2022-10-13T12:59:05","slug":"dave-h","status":"publish","type":"post","link":"https:\/\/www.cancerresearch.org\/es\/blog\/dave-h","title":{"rendered":"Dave Healy’s Immunotherapy Story"},"content":{"rendered":"\n

Kidney Cancer |  Diagnosed 2009<\/strong><\/p>\n\n\n\n

Son como tres peque\u00f1as punciones subcut\u00e1neas. Nada m\u00e1s.<\/p><\/blockquote>\n\n\n\n

La historia de Dave<\/h2>\n\n\n\n

Febrero de 2009 no fue un buen mes para David Healy. A los 44 a\u00f1os, a David (esposo y padre de tres ni\u00f1os) lo despidieron de su trabajo como mec\u00e1nico de autom\u00f3viles. De regreso a casa cargando por \u00faltima vez su pesada caja de herramientas, sinti\u00f3 un dolor en la zona lumbar. Al d\u00eda siguiente, se despert\u00f3 con un enervante dolor de espalda. Fue a un centro de atenci\u00f3n de urgencias y los m\u00e9dicos le dijeron que probablemente ten\u00eda c\u00e1lculos en la ves\u00edcula biliar. Le hicieron m\u00e1s ex\u00e1menes que arrojaron un diagn\u00f3stico mucho peor: c\u00e1ncer de ri\u00f1\u00f3n metast\u00e1sico en estadio IV.
 
El c\u00e1ncer de ri\u00f1\u00f3n es un c\u00e1ncer dif\u00edcil de tratar. Como a menudo no presenta s\u00edntomas en sus primeros estadios, es posible que no se diagnostique hasta despu\u00e9s de haberse diseminado a otras partes del cuerpo. Cuando se detecta en estadios avanzados, muchas veces es resistente a la quimioterapia, la radioterapia y las terapias hormonales. Los tratamientos dirigidos, como los inhibidores del VEGF, suelen ser el tratamiento de primera l\u00ednea, pero se necesitan mejores tratamientos, en particular para pacientes como David que reciben el diagn\u00f3stico cuando la enfermedad ya ha avanzado.
 
Por recomendaci\u00f3n del Dr. Arkadiusz Dudek, Ph. D.,<\/a> onc\u00f3logo del Masonic Cancer Center de la Universidad de Minnesota, David se inscribi\u00f3 en un estudio cl\u00ednico de fase 2 en el que se evaluaba un inhibidor de VEGF aprobado denominado sunitinib (Sutent\u00ae), adem\u00e1s de una inmunoterapia experimental denominada AGS-003<\/a>, desarrollada por Argos Therapeutics. La AGS-003 es una inmunoterapia personalizada contra el c\u00e1ncer dise\u00f1ada para ayudar al sistema inmunitario a reconocer y combatir las c\u00e9lulas cancerosas. Para producir AGS-003, las c\u00e9lulas dendr\u00edticas se obtienen de los propios gl\u00f3bulos blancos del paciente. Luego, se las carga con ant\u00edgenos tumorales del propio tumor del paciente. Una vez que las c\u00e9lulas dendr\u00edticas han sido \u00abeducadas\u00bb con estos ant\u00edgenos para reconocer el tumor del paciente, se vuelven a inyectar en el paciente de forma regular, donde estimular\u00e1n a los linfocitos T para que combatan las c\u00e9lulas cancerosas restantes. <\/p>\n\n\n\n

Preguntas y respuestas<\/h2>\n\n\n\n\n

Al principio me quejaba de dolor de espalda y los m\u00e9dicos pensaron que ten\u00eda c\u00e1lculos biliares. Pensaron que ser\u00eda mejor hacer una ecograf\u00eda para ver cu\u00e1ntos ten\u00eda. En ese momento, todav\u00eda estaba en el centro de atenci\u00f3n de urgencia. Fui a casa a buscar a mi esposa porque ya no pod\u00eda conducir, me dol\u00eda mucho. Luego fuimos al hospital para hacerme la ecograf\u00eda. Mientras est\u00e1bamos en la sala de espera, son\u00f3 el tel\u00e9fono. No respond\u00ed. Mi esposa atendi\u00f3 y ah\u00ed fue cuando nos dijeron que ten\u00eda c\u00e1ncer de ri\u00f1\u00f3n. Fue una conmoci\u00f3n total para los dos, a pesar del dolor que sent\u00eda pens\u00e9 que iba a tener que levantar a mi esposa del piso.<\/p>\n\n\n\n\n\n

Me extirparon el ri\u00f1\u00f3n; esa era la principal preocupaci\u00f3n porque supongo que el tumor era bastante grande. Luego me derivaron con el Dr. Dudek, quien me habl\u00f3 del estudio de investigaci\u00f3n.
\u00a0
Me dijeron que entre la inmunoterapia y el Sutent, las lesiones que a\u00fan ten\u00eda deber\u00edan reducirse. Tuve un par de lesiones en los pulmones y el h\u00edgado, y casi todas ya han desaparecido. La del h\u00edgado desapareci\u00f3 por completo.<\/p>\n\n\n\n\n\n

Cada tres meses iba por mis vacunas. Se dan justo debajo de las axilas y son como tres peque\u00f1as punciones subcut\u00e1neas, nada m\u00e1s. Luego me controlaban un rato para asegurarse de que no tuviera ninguna reacci\u00f3n a los medicamentos ni a nada. Por lo general, tarda aproximadamente una hora.<\/p>\n\n\n\n

Tiene algunos efectos secundarios, pero son f\u00e1ciles de controlar. Me duele un poco la boca y los pies, pero es tolerable.<\/p>\n\n\n\n\n\n

Recibir el diagn\u00f3stico de c\u00e1ncer fue una gran conmoci\u00f3n y nos cambi\u00f3 a toda la familia. Pero saber que este tratamiento me est\u00e1 ayudando y que en cierto modo me estoy curando, creo que nos permite sobrellevar bastante bien la situaci\u00f3n, considerando las circunstancias.<\/p>\n\n\n\n\n\n

Mi consejo ser\u00eda que lo intenten. Pude ver que el c\u00e1ncer desaparec\u00eda, por lo que recomendar\u00eda muy especialmente este procedimiento.<\/p>\n\n","protected":false},"excerpt":{"rendered":"

Kidney Cancer |  Diagnosed 2009 Son como tres peque\u00f1as punciones subcut\u00e1neas. Nada m\u00e1s. La historia de Dave Febrero de 2009 no fue un buen mes para David Healy. A los 44 a\u00f1os, a […]<\/p>\n","protected":false},"author":22,"featured_media":21939,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[678],"tags":[687,439],"resource_cancer_types":[],"resource_patient_age":[],"resource_cancer_stage":[],"resource_treatment_type":[],"resource_treatment_status":[],"class_list":["post-26054","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-patient-story-es","tag-kidney-cancer-es","tag-patient-stories-es"],"acf":[],"yoast_head":"\nDave Healy's Immunotherapy Story - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/blog\/dave-h\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dave Healy's Immunotherapy Story - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"Kidney Cancer |  Diagnosed 2009 Son como tres peque\u00f1as punciones subcut\u00e1neas. 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