B cells and the antibodies they produce are increasingly recognized as important players in cancer immunity. In several cancers, patients whose tumors contain high numbers of B cells respond better to immunotherapy and have improved survival. However, scientists still do not know exactly what these B cell responses are recognizing or whether consistent immune \u201cfingerprints\u201d exist across patients. <\/p>\n\n\n\n
Dr. Glaros has spent his career studying how B cells develop, diversify, and form long-lasting immune memory. His earlier research challenged long-standing assumptions about how memory B cells arise and established him as a leading young investigator in fundamental B cell biology. <\/p>\n\n\n\n
One of the biggest challenges in studying B cells is their enormous diversity: every person\u2019s B cells are slightly different, making it difficult to identify meaningful patterns. To overcome this obstacle, Dr. Glaros will use a novel experimental system in which B cell diversity is intentionally simplified and more reproducible. Using this approach, he will compare immune responses across different tumor settings to determine whether cancers produce recognizable B cell signatures. The goal is to identify immune fingerprints that could improve cancer monitoring, help classify disease more accurately, and deepen understanding of how the immune system responds to tumors. <\/p>\n\n\n\n
Dr. Glaros\u2019 research could ultimately lead to new ways of predicting disease progression and tailoring immunotherapy based on a patient\u2019s unique immune response. <\/p>\n\n\n\n
Gabriel Victora, PhD<\/strong><\/p>\n\n\n\n Towards identification of cancer-specific fingerprints in B cell repertoires<\/strong><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":" B cells and the antibodies they produce are increasingly recognized as important players in cancer immunity. In several cancers, patients whose tumors contain high numbers of B cells respond better to immunotherapy […]<\/p>\n","protected":false},"featured_media":39670,"template":"","tax_cancer_type":[365,362,356,351],"tax_grant_type":[890],"tax_award_year":[881],"tax_institutions":[510],"tax_location_states":[494],"class_list":["post-39731","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Irvington Postdoctoral Fellow","quote":"","scientist_last_name":"Glaros","show_on_landing":true,"scientist_publish_until":"20290727"},"yoast_head":"\nProjects and Grants<\/h2>\n\n\n\n