{"id":39054,"date":"2026-07-01T19:14:36","date_gmt":"2026-07-01T23:14:36","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=39054"},"modified":"2026-07-08T11:43:02","modified_gmt":"2026-07-08T15:43:02","slug":"james-swann-bvetmed-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/james-swann-bvetmed-phd","title":{"rendered":"James Swann, VetMB, DPhil"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Many cancers, including breast cancer, cause blood stem cells in the bone marrow to change their activity, leading to the formation of abnormal myeloid-derived suppressor cells (MDSCs). These MDSCs return to the tumor, where they prevent the body\u2019s immune system from targeting cancer cells and also interfere with anti-cancer treatments. MDCSs are found in many tumor types, and higher numbers are associated with worse survival for cancer patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In this proposal, Dr. Swann will investigate the signals and cellular mechanisms that cause blood stem cells to make MDSCs, to prevent MDSC formation and improve the effectiveness of anti-cancer immune therapies for tumor types such as breast and other solid tumors.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Swann originally trained as a veterinarian at the University of Cambridge before shifting towards immunology research in his PhD at Oxford. Through his PhD and postdoctoral fellowship work, he has contributed deeply to the fundamental understanding of hematology and hematopoietic stem cells. He is currently pursuing his postdoctoral work at Columbia University.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mentors<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Emmanuelle Passegu\u00e9, PhD, Raul Rabadan, PhD<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><strong>Role of YBX1 in myeloid-derived suppressor cell emergence and function<\/strong><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Many cancers, including breast cancer, cause blood stem cells in the bone marrow to change their activity, leading to the formation of abnormal myeloid-derived suppressor cells (MDSCs). These MDSCs return to the [&hellip;]<\/p>\n","protected":false},"featured_media":39041,"template":"","tax_cancer_type":[365,356],"tax_grant_type":[883],"tax_award_year":[881],"tax_institutions":[623],"tax_location_states":[494],"class_list":["post-39054","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"IGNITE Fellow","quote":"","scientist_last_name":"Swann","show_on_landing":true,"scientist_publish_until":"20290701"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>James Swann, VetMB, DPhil - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/james-swann-bvetmed-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"James Swann, VetMB, DPhil - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"Many cancers, including breast cancer, cause blood stem cells in the bone marrow to change their activity, leading to the formation of abnormal myeloid-derived suppressor cells (MDSCs). 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