{"id":36868,"date":"2025-12-12T18:18:12","date_gmt":"2025-12-12T23:18:12","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=36868"},"modified":"2025-12-12T18:18:14","modified_gmt":"2025-12-12T23:18:14","slug":"zhouping-hong-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/zhouping-hong-phd","title":{"rendered":"Zhouping Hong, PhD"},"content":{"rendered":"\n<p>The innate immune system serves as the body\u2019s first line of defense against infection and injury, relying on inflammasomes\u2013molecular signaling platforms that detect danger and trigger inflammation. Each inflammasome is built from a family of proteins known as NOD-like receptors (NLRs), but how these individual inflammasomes might cooperate with one another remains an open question in immunology. Dr. Zhouping Hong\u2019s research explores the bold idea that different NLRs can assemble together into \u201csuper-inflammasome\u201d complexes\u2014coordinated structures that amplify immune signaling and may play key roles in inflammation, autoimmune disease, and cancer.<\/p>\n\n\n\n<p>Focusing on two major inflammasomes, NLRP3 and NLRP1, Dr. Hong is combining advanced biochemical, biophysical, and structural approaches to uncover how these complexes form and function. Her studies aim to determine whether the two inflammasomes physically interact, how this cooperation enhances immune activation, and what molecular mechanisms govern their assembly. By establishing the first mechanistic framework for super-inflammasome formation, this work could transform our understanding of how innate immunity is regulated and identify new therapeutic targets for inflammation-driven diseases.<\/p>\n\n\n\n<p>Dr. Hong is a biochemist and structural biologist whose research bridges molecular mechanisms and immune regulation. Her expertise spans biochemistry, membrane biology, and structural immunology, and she has made key discoveries on lipid transport between organelles and protein\u2013lipid interactions. Now applying this rigorous training to innate immunity, she is uncovering how inflammasome networks coordinate immune defense\u2014insights that could ultimately guide new strategies to control inflammation and treat immune-related disorders.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sponsor<\/h2>\n\n\n\n<p><strong>Hao Wu, PhD<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p><strong>Investigating the NLRP3 and NLRP1 super-inflammasome<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The innate immune system serves as the body\u2019s first line of defense against infection and injury, relying on inflammasomes\u2013molecular signaling platforms that detect danger and trigger inflammation. Each inflammasome is built from [&hellip;]<\/p>\n","protected":false},"featured_media":36851,"template":"","tax_cancer_type":[455],"tax_grant_type":[486],"tax_award_year":[742],"tax_institutions":[489],"tax_location_states":[490],"class_list":["post-36868","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Irvington Postdoctoral Fellow","quote":"","scientist_last_name":"Hong","show_on_landing":true,"scientist_publish_until":"20281213"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Zhouping Hong, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zhouping-hong-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zhouping Hong, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"The innate immune system serves as the body\u2019s first line of defense against infection and injury, relying on inflammasomes\u2013molecular signaling platforms that detect danger and trigger inflammation. 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