{"id":35722,"date":"2025-07-16T03:28:19","date_gmt":"2025-07-16T07:28:19","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=35722"},"modified":"2025-07-16T03:28:20","modified_gmt":"2025-07-16T07:28:20","slug":"matthew-krummel-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/matthew-krummel-phd","title":{"rendered":"Matthew Krummel, PhD"},"content":{"rendered":"\n<p>Traditional cancer therapies often rely on a single drug to do the job, but tumors are complex ecosystems filled with different types of cells interacting in intricate ways. Knowing this, Drs. Allon Wagner, Alexis Combes, Arpita Desai, and Matthew Krummel are rethinking how to fight cancer by shifting the focus from one big punch to a series of well-timed nudges. Their bold idea: what if we could gently steer that ecosystem back to health?<\/p>\n\n\n\n<p>Together the team is developing \u201cnudge drugs\u201d \u2013 treatments that may not work alone, but when given in a smart sequence, help reawaken the immune system and gradually push the tumor environment toward lasting tumor control. They will use tumor samples from patients with kidney cancer to test how the tissue responds to different drugs and map out the many possible \u201cstates\u201d a tumor can move through. <\/p>\n\n\n\n<p>Dr. Wagner, Combes, Desai, Krummel will then train an algorithm to predict which drug combinations might best guide the tumor toward a state the immune system can defeat. This nuanced, data-driven strategy aims to transform how cancer is treated by working with the body\u2019s natural defenses, one smart step at a time<a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Research Focus<\/h2>\n\n\n\n<p><strong>Kidney cancer, combination therapy, machine learning<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p><strong>Towards nudge drugs: An iterative, integrated computational and experimental pipeline for discovery of immune-checkpoint blockade nudge drug candidates<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Traditional cancer therapies often rely on a single drug to do the job, but tumors are complex ecosystems filled with different types of cells interacting in intricate ways. Knowing this, Drs. Allon [&hellip;]<\/p>\n","protected":false},"featured_media":35669,"template":"","tax_cancer_type":[359],"tax_grant_type":[481],"tax_award_year":[742],"tax_institutions":[500],"tax_location_states":[501],"class_list":["post-35722","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"Technology Impact Award Investigators","quote":"","scientist_last_name":"Krummel","show_on_landing":true,"scientist_publish_until":"20280715"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Matthew Krummel, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matthew-krummel-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Matthew Krummel, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"Traditional cancer therapies often rely on a single drug to do the job, but tumors are complex ecosystems filled with different types of cells interacting in intricate ways. 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