{"id":35717,"date":"2025-07-16T03:13:35","date_gmt":"2025-07-16T07:13:35","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=35717"},"modified":"2025-07-16T03:13:36","modified_gmt":"2025-07-16T07:13:36","slug":"debattama-sen-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/debattama-sen-phd","title":{"rendered":"Debattama Sen, PhD"},"content":{"rendered":"\n<p>CAR T cells, often called \u201cliving drugs,\u201d are engineered from a patient\u2019s own immune cells to hunt down and kill cancer. Although CAR T cells have been a breakthrough treatment for patients with blood cancers, their effects can be short-lived, and they are not yet effective for all patients or for all cancer types. Drs. Debattama Sen and Robert Manguso are on a mission to make CAR T-cell therapy work better, for more people, and for longer.<\/p>\n\n\n\n<p>Together they are investigating the rare CAR T cells that are especially powerful \u2013 those that can kill cancer cells over and over again, a phenomenon known as \u201cserial killing.\u201d The team created a new platform that tracks which specific CAR T cells kill which cancer cells. To kill a cancer cell, or initiate cell death, CAR T cells release a molecule called Granzyme B. When this happens, the \u201ckiss of death\u201d platform is activated and the cancer cell marks or tags the specific CAR T cell\u00a0 that killed it. The more tags a CAR T cell picks up, the more potent it is.<\/p>\n\n\n\n<p>By studying these high-performing CAR T cells and running large-scale genetic screens, Drs. Sen and Manguso aim to uncover what makes a CAR T cell a true cancer killer and how to engineer more of them. It&#8217;s a bold approach with the potential to boost CAR T-cell therapy for patients battling blood cancers and solid tumors.<a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Research Focus<\/h2>\n\n\n\n<p><strong>CAR T-cell therapy, solid tumors, genetic screens<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p><strong>Engineering \u00abserial killer\u00bb T cells to enhance CAR T-cell efficacy in solid tumors<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>CAR T cells, often called \u201cliving drugs,\u201d are engineered from a patient\u2019s own immune cells to hunt down and kill cancer. Although CAR T cells have been a breakthrough treatment for patients [&hellip;]<\/p>\n","protected":false},"featured_media":35661,"template":"","tax_cancer_type":[455],"tax_grant_type":[481],"tax_award_year":[742],"tax_institutions":[543],"tax_location_states":[490],"class_list":["post-35717","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"Technology Impact Award Investigators","quote":"","scientist_last_name":"Sen","show_on_landing":true,"scientist_publish_until":"20280715"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Debattama Sen, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/debattama-sen-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Debattama Sen, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"CAR T cells, often called \u201cliving drugs,\u201d are engineered from a patient\u2019s own immune cells to hunt down and kill cancer. 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