{"id":35711,"date":"2025-07-16T02:21:41","date_gmt":"2025-07-16T06:21:41","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=35711"},"modified":"2025-07-16T02:21:42","modified_gmt":"2025-07-16T06:21:42","slug":"nicolas-vabret-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/nicolas-vabret-phd","title":{"rendered":"Nicolas Vabret, PhD"},"content":{"rendered":"\n<p>As people age, changes in the immune system can fuel tumor growth and reduce the body&#8217;s ability to respond to immunotherapy. One key contributor is the reactivation of transposable elements (TEs) \u2013 \u201cjumping\u201d segments of DNA that are normally inactive and have no function. In cancer, TEs can trigger inflammation and promote immune-suppressing cells, weakening the body\u2019s defenses. Dr. Nicolas Vabret is investigating how TE-driven inflammation contributes to cancer progression and resistance to immunotherapy, particularly in older individuals.<\/p>\n\n\n\n<p>Dr. Vabret\u2019s research has shown that lamivudine, an FDA-approved drug used to treat HIV and hepatitis B, can block TE activity. In animal models of lung and colorectal cancer, lamivudine reduced harmful immune responses, slowed tumor growth, and improved survival. His ongoing clinical trial is testing lamivudine in combination with immune checkpoint inhibitors in patients with advanced cancers who are no longer responding to standard treatment.<\/p>\n\n\n\n<p>This project will examine how lamivudine affects immune-suppressing cells and TE activity, providing valuable insights into TE-driven inflammation and offering potential strategies to enhance existing immunotherapy treatments.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Research Focus<\/h2>\n\n\n\n<p><strong>Lung cancer, colorectal cancer, aging<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p><strong>Reverse transcriptase inhibition to deter pro-tumorigenic myelopoiesis in patients with solid tumors<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>As people age, changes in the immune system can fuel tumor growth and reduce the body&#8217;s ability to respond to immunotherapy. One key contributor is the reactivation of transposable elements (TEs) \u2013 [&hellip;]<\/p>\n","protected":false},"featured_media":35667,"template":"","tax_cancer_type":[362,356],"tax_grant_type":[485],"tax_award_year":[742],"tax_institutions":[540],"tax_location_states":[494],"class_list":["post-35711","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CLIP Investigator","quote":"","scientist_last_name":"Vabret","show_on_landing":true,"scientist_publish_until":"20280715"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nicolas Vabret, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/nicolas-vabret-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nicolas Vabret, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"As people age, changes in the immune system can fuel tumor growth and reduce the body&#8217;s ability to respond to immunotherapy. 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