{"id":35709,"date":"2025-07-16T02:11:34","date_gmt":"2025-07-16T06:11:34","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&p=35709"},"modified":"2025-07-16T02:11:35","modified_gmt":"2025-07-16T06:11:35","slug":"filipe-pereira-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/filipe-pereira-phd","title":{"rendered":"Filipe Pereira, PhD"},"content":{"rendered":"\n

Melanoma is a skin cancer whose incidence has risen by 27% annually over the past decade. While immunotherapy has revolutionized melanoma treatment, many melanomas, particularly those that are \u201ccold\u201d, or treatment-resistant, fail to respond to current therapies. Dr. Filipe Pereira\u2019s research focuses on novel strategies to overcome resistance in these cold tumors and enhance the effectiveness of immunotherapy.<\/p>\n\n\n\n

Dr. Pereira\u2019s approach relies on tertiary lymphoid structures (TLS), which are specialized immune cell clusters that form within tumors and act as local immune centers. His team recently developed a novel mechanism by which to create TLS \u2013 by reprogramming cancer cells into dendritic cells \u2013 and changed \u201ccold\u201d tumors into \u201chot\u201d tumors that were more responsive to immunotherapy. <\/p>\n\n\n\n

In this project, Dr. Pereira\u2019s team will investigate whether this reprogramming strengthens anti-tumor immunity and promotes TLS formation as well as identify the key cell types and molecular signals involved in TLS development. His long-term goal is to develop a dual-action gene therapy that combines immune cell activation with immune center coordination to shift the balance in favor of the immune system\u2019s fight against cancer.<\/p>\n\n\n\n

Research Focus<\/h2>\n\n\n\n

Melanoma, gene therapy, \u201ccold\u201d tumors<\/strong><\/p>\n\n\n\n

Projects and Grants<\/h2>\n\n\n\n

Engineering synthetic tertiary lymphoid structures in melanoma with dendritic cell reprogramming<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Melanoma is a skin cancer whose incidence has risen by 27% annually over the past decade. 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