{"id":35703,"date":"2025-07-16T01:43:24","date_gmt":"2025-07-16T05:43:24","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=35703"},"modified":"2025-07-23T12:50:39","modified_gmt":"2025-07-23T16:50:39","slug":"sidi-chen-phd-2","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/sidi-chen-phd-2","title":{"rendered":"Sidi Chen, PhD"},"content":{"rendered":"\n<p>CAR T-cell therapy has revolutionized blood cancer treatment, but it hasn\u2019t yet cracked the code for solid tumors like kidney cancer. Solid tumors create tough environments that block immune responses, hide behind varied antigens, and prevent immune cells from getting inside. This often reduces the effectiveness of CAR T-cell therapy and leads to resistance or relapse.<\/p>\n\n\n\n<p>Dr. Sidi Chen is taking a new approach to CAR T-cell therapy and doubling the number of ways in which it can fight against late-stage kidney cancer. He has created CAR-T-drug conjugates that seek out and destroy cancer cells and also deliver chemotherapy drugs precisely where they are needed \u2013 right to the tumor itself \u2013 by using a clever \u201cclick\u201d chemistry that attaches drugs directly to CAR T cells.<\/p>\n\n\n\n<p>Dr. Chen\u2019s team is now working to refine this strategy, testing new combinations of CAR T-cell therapies and chemotherapy drugs and validating the results in animal models. If successful, this innovative approach could finally bring the power of CAR T-cell therapy to solid tumors and change the game for patients with difficult-to-treat kidney cancer.<a id=\"_msocom_1\"><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Research Focus<\/h2>\n\n\n\n<p><strong>Kidney cancer, CAR T cells, combination therapy<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p><strong>Initial development of CAR-T-drug conjugate against solid tumor and application in kidney cancer<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>CAR T-cell therapy has revolutionized blood cancer treatment, but it hasn\u2019t yet cracked the code for solid tumors like kidney cancer. Solid tumors create tough environments that block immune responses, hide behind [&hellip;]<\/p>\n","protected":false},"featured_media":35659,"template":"","tax_cancer_type":[359],"tax_grant_type":[485],"tax_award_year":[742],"tax_institutions":[498],"tax_location_states":[499],"class_list":["post-35703","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Kidney Cancer Association CLIP Investigator","quote":"","scientist_last_name":"Chen","show_on_landing":true,"scientist_publish_until":"20280715"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sidi Chen, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/sidi-chen-phd-2\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sidi Chen, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"CAR T-cell therapy has revolutionized blood cancer treatment, but it hasn\u2019t yet cracked the code for solid tumors like kidney cancer. 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