{"id":35701,"date":"2025-07-16T01:34:27","date_gmt":"2025-07-16T05:34:27","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=35701"},"modified":"2025-07-16T01:34:29","modified_gmt":"2025-07-16T05:34:29","slug":"david-braun-md-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/david-braun-md-phd","title":{"rendered":"David Braun, MD, PhD"},"content":{"rendered":"\n<p>Immune checkpoint inhibitors are a common treatment for solid tumors, but for many patients, these drugs don\u2019t work or stop working over time. This can happen when the tumor becomes resistant, or no longer responds to treatment. Recruiting T cells to the tumor can be effective in many cancer types, but most kidney cancers are already flooded with T cells, leading scientists to look for different approaches. <\/p>\n\n\n\n<p>Dr. David Braun\u2019s research is designed to get a complete picture of what is happening in the kidney tumor microenvironment. First, he will map the unique \u00abflags\u00bb (or antigens) that kidney cancer cells display. Then, he will test to see what specific types of immune cells actually make it into tumors and are able to recognize and attack those targets. The ultimate goal is to design smarter, more precise immunotherapies that steer the immune system directly toward cancer cells. Dr. Braun hopes to quickly move these insights into clinical trials, bringing new hope to patients with advanced kidney cancer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Research Focus<\/h2>\n\n\n\n<p><strong>Kidney cancer, tumor microenvironment, T cells<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p><strong>Development of antigen-directed therapies for renal cell carcinoma<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Immune checkpoint inhibitors are a common treatment for solid tumors, but for many patients, these drugs don\u2019t work or stop working over time. This can happen when the tumor becomes resistant, or [&hellip;]<\/p>\n","protected":false},"featured_media":35685,"template":"","tax_cancer_type":[359],"tax_grant_type":[485],"tax_award_year":[742],"tax_institutions":[498],"tax_location_states":[499],"class_list":["post-35701","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CLIP Investigator","quote":"","scientist_last_name":"Braun","show_on_landing":true,"scientist_publish_until":"20280715"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>David Braun, MD, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/david-braun-md-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"David Braun, MD, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"Immune checkpoint inhibitors are a common treatment for solid tumors, but for many patients, these drugs don\u2019t work or stop working over time. 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