{"id":35599,"date":"2025-06-27T15:29:58","date_gmt":"2025-06-27T19:29:58","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=35599"},"modified":"2025-07-01T11:42:08","modified_gmt":"2025-07-01T15:42:08","slug":"tyler-park","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/tyler-park","title":{"rendered":"Tyler Park, PhD"},"content":{"rendered":"\n<p>Immune tolerance protects the body from autoimmune disease by preventing the immune system from attacking normal tissues. But, this protective mechanism can also shield cancer cells from immune attack. A key player in this process is a gene called <em>AIRE<\/em>, which trains developing immune cells in the thymus to recognize and ignore the body\u2019s own proteins.<\/p>\n\n\n\n<p>Dr. Tyler Park\u2019s research aims to better understand how AIRE works at the molecular level \u2013 specifically, how it helps thymic cells display these \u201cself\u201d proteins and eliminate harmful immune cells before they mature. By using computational and statistical tools, he will map the proteins AIRE interacts with and the pathways it controls. His work will also investigate how dysregulation of these processes might contribute to immune escape in cancer or the development of autoimmune conditions. \u201cWe seek to uncover how AIRE functions and ultimately how immune tolerance is regulated, with the goal of improving immunotherapies while minimizing the risk of autoimmune diseases,\u201d he explains. The foundation of Dr. Park\u2019s research lies in \u201cleveraging mathematical and statistical principles to understand biological processes and diseases.\u201d He earned his PhD in computational biology at Princeton University, where he developed an algorithm called the SuperDendrix to identify genes essential for cancer survival and the somatic mutations that explain their molecular basis. He also developed a statistical framework to predict drug-target interactions using drug response and CRISPR screens. Now as a postdoctoral fellow, Dr. Park applies machine learning and multiomic analyses to investigate immune tolerance and uncover actionable insights into immune regulation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sponsor<\/h2>\n\n\n\n<p><strong>Christina Leslie, PhD, and Chrysothemis Brown, MBBS, PhD<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Research Focus<\/h2>\n\n\n\n<p><strong>Immune tolerance, autoimmunity, immune evasion<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p><strong>Role of AIRE in thymic tolerance to T cells<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Immune tolerance protects the body from autoimmune disease by preventing the immune system from attacking normal tissues. But, this protective mechanism can also shield cancer cells from immune attack. A key player [&hellip;]<\/p>\n","protected":false},"featured_media":35517,"template":"","tax_cancer_type":[455],"tax_grant_type":[486],"tax_award_year":[742],"tax_institutions":[493],"tax_location_states":[494],"class_list":["post-35599","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Immuno-Informatics Postdoctoral Fellow","quote":"","scientist_last_name":"Park","show_on_landing":true,"scientist_publish_until":"20280629"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Tyler Park, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/tyler-park\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tyler Park, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"Immune tolerance protects the body from autoimmune disease by preventing the immune system from attacking normal tissues. 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