{"id":35589,"date":"2025-06-27T14:37:37","date_gmt":"2025-06-27T18:37:37","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=35589"},"modified":"2025-06-27T14:38:51","modified_gmt":"2025-06-27T18:38:51","slug":"katherine-lindblad-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/katherine-lindblad-phd","title":{"rendered":"Katherine Lindblad, PhD"},"content":{"rendered":"\n<p>Hepatocellular carcinoma (HCC) remains one of the deadliest cancers worldwide, with limited response rates to current T-cell-boosting immunotherapies. About two-thirds of patients with HCC have impaired activity in another immune cell type called dendritic cells (DCs). \u201cThis makes targeting DCs a promising and underexplored avenue in HCC,\u201d says Dr. Katherine Lindblad.<\/p>\n\n\n\n<p>Dr. Lindblad\u2019s project will focus on a unique activation state of DCs, called hyperactivated (hDCs). Unlike conventional DC activation, hDCs exhibit superior migration, cytokine secretion, and memory T-cell induction. She will establish a rules-based platform for leveraging hDC behavior and assess their potential to induce protective T-cell responses. These findings could inform next-generation DC-based immunotherapies not only for HCC, but across multiple cancer types. Dr. Lindblad\u2019s personal experiences instilled in her \u201can insatiable drive to understand the defining features of &#8216;healthy&#8217; and the etiology of disease.\u201d While she had a long-standing interest in translational biomedical research, it was clinical trial work at the National Heart, Lung, and Blood Institute that led her to commit to a career in cancer immunology research. \u201c[It] gave me a profound appreciation for the impact of bench-to-bedside science. Sample 10 was never just a number \u2013 but a person, a family, pain, and hope.\u201d Dr. Lindblad subsequently completed her PhD at the Icahn School of Medicine at Mount Sinai, with a focus on how tumor-intrinsic genetics shape immunity in liver cancer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sponsor<\/h2>\n\n\n\n<p><strong>Jonathan Kagan, PhD<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Research Focus<\/h2>\n\n\n\n<p><strong>Hepatocellular carcinoma, dendritic cells, innate immunity<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p><strong>Hijacking dendritic cell-intrinsic NLRP3 inflammasome to drive protective immunity in liver cancer<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hepatocellular carcinoma (HCC) remains one of the deadliest cancers worldwide, with limited response rates to current T-cell-boosting immunotherapies. About two-thirds of patients with HCC have impaired activity in another immune cell type [&hellip;]<\/p>\n","protected":false},"featured_media":35539,"template":"","tax_cancer_type":[455],"tax_grant_type":[486],"tax_award_year":[742],"tax_institutions":[489],"tax_location_states":[490],"class_list":["post-35589","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Irvington Postdoctoral Fellow","quote":"","scientist_last_name":"Lindblad","show_on_landing":true,"scientist_publish_until":"20280629"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Katherine Lindblad, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/katherine-lindblad-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Katherine Lindblad, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"Hepatocellular carcinoma (HCC) remains one of the deadliest cancers worldwide, with limited response rates to current T-cell-boosting immunotherapies. 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