{"id":35572,"date":"2025-06-26T17:13:38","date_gmt":"2025-06-26T21:13:38","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=35572"},"modified":"2025-06-27T13:51:58","modified_gmt":"2025-06-27T17:51:58","slug":"zachary-earley-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/zachary-earley-phd","title":{"rendered":"Zachary Earley, PhD"},"content":{"rendered":"\n<p>In the gut, a special class of immune cells called intestinal intraepithelial lymphocytes (IELs) act as frontline defenders against infection and inflammation. When these cells don\u2019t function properly, it can lead to serious diseases like inflammatory bowel disease (IBD) and colorectal cancer. In this project, Dr. Zachary Earley will investigate how IELs develop, migrate, and become \u201clong lived\u201d to maintain gut-immune balance \u2013 and the G\u03b113\/GPR132 signaling pathway may be the key.<\/p>\n\n\n\n<p>The G\u03b113\/GPR132 signaling pathway allows cells to sense and respond to environmental signals. Without G\u03b113, IELs fail to survive in the gut, though they remain healthy elsewhere in the body, making it a unique marker to use for manipulations. Dr. Earley hypothesizes that blocking this pathway may actually protect against gut inflammation, pointing to a possible new treatment for intestinal autoimmune diseases. \u201cUnderstanding how these diseases develop and finding novel approaches to treat them is what motivates me to pursue a career in science,\u201d Dr. Earley says. In his doctoral work at the University of Chicago, he uncovered how intestinal epithelial cells \u2013 cells that line the inside of the intestines \u2013 regulate microbial colonization and influence inflammation in diseases like celiac disease. He also revealed how an antibody called IgA maintains immune homeostasis and controls the microbiota. Now, Dr. Earley is focused on uncovering tissue-specific immune signaling pathways, like G\u03b113, that may hold the key to treating chronic intestinal diseases without systemic immune suppression.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sponsor<\/h2>\n\n\n\n<p><strong>Jason Cyster, PhD<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Research Focus<\/h2>\n\n\n\n<p><strong>Inflammatory bowel disease, colorectal cancer, gut-immune balance<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p><strong>G\u03b113 signaling in intestinal epithelial lymphocyte homeostasis<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the gut, a special class of immune cells called intestinal intraepithelial lymphocytes (IELs) act as frontline defenders against infection and inflammation. When these cells don\u2019t function properly, it can lead to [&hellip;]<\/p>\n","protected":false},"featured_media":35583,"template":"","tax_cancer_type":[455],"tax_grant_type":[486],"tax_award_year":[742],"tax_institutions":[500],"tax_location_states":[501],"class_list":["post-35572","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Irvington Postdoctoral Fellow","quote":"","scientist_last_name":"Earley","show_on_landing":true,"scientist_publish_until":"20280629"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Zachary Earley, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zachary Earley, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"In the gut, a special class of immune cells called intestinal intraepithelial lymphocytes (IELs) act as frontline defenders against infection and inflammation. When these cells don\u2019t function properly, it can lead to [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd\" \/>\n<meta property=\"og:site_name\" content=\"Cancer Research Institute\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-27T17:51:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/headshot-zach-earley-v2.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd\",\"url\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd\",\"name\":\"Zachary Earley, PhD - Cancer Research Institute\",\"isPartOf\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/headshot-zach-earley-v2.webp\",\"datePublished\":\"2025-06-26T21:13:38+00:00\",\"dateModified\":\"2025-06-27T17:51:58+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd#primaryimage\",\"url\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/headshot-zach-earley-v2.webp\",\"contentUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/headshot-zach-earley-v2.webp\",\"width\":800,\"height\":800,\"caption\":\"Zach Earley\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.cancerresearch.org\/es\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Zachary Earley, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.cancerresearch.org\/#website\",\"url\":\"https:\/\/www.cancerresearch.org\/\",\"name\":\"Cancer Research Institute\",\"description\":\"For a World Immune to Cancer\",\"publisher\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.cancerresearch.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.cancerresearch.org\/#organization\",\"name\":\"Cancer Research Institute\",\"url\":\"https:\/\/www.cancerresearch.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg\",\"contentUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg\",\"width\":156,\"height\":53,\"caption\":\"Cancer Research Institute\"},\"image\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Zachary Earley, PhD - Cancer Research Institute","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd","og_locale":"es_ES","og_type":"article","og_title":"Zachary Earley, PhD - Cancer Research Institute","og_description":"In the gut, a special class of immune cells called intestinal intraepithelial lymphocytes (IELs) act as frontline defenders against infection and inflammation. When these cells don\u2019t function properly, it can lead to [&hellip;]","og_url":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd","og_site_name":"Cancer Research Institute","article_modified_time":"2025-06-27T17:51:58+00:00","og_image":[{"width":800,"height":800,"url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/headshot-zach-earley-v2.webp","type":"image\/webp"}],"twitter_card":"summary_large_image","twitter_misc":{"Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd","url":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd","name":"Zachary Earley, PhD - Cancer Research Institute","isPartOf":{"@id":"https:\/\/www.cancerresearch.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd#primaryimage"},"image":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd#primaryimage"},"thumbnailUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/headshot-zach-earley-v2.webp","datePublished":"2025-06-26T21:13:38+00:00","dateModified":"2025-06-27T17:51:58+00:00","breadcrumb":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd"]}]},{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd#primaryimage","url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/headshot-zach-earley-v2.webp","contentUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/headshot-zach-earley-v2.webp","width":800,"height":800,"caption":"Zach Earley"},{"@type":"BreadcrumbList","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/zachary-earley-phd#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.cancerresearch.org\/es"},{"@type":"ListItem","position":2,"name":"Zachary Earley, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.cancerresearch.org\/#website","url":"https:\/\/www.cancerresearch.org\/","name":"Cancer Research Institute","description":"For a World Immune to Cancer","publisher":{"@id":"https:\/\/www.cancerresearch.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.cancerresearch.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/www.cancerresearch.org\/#organization","name":"Cancer Research Institute","url":"https:\/\/www.cancerresearch.org\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/","url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg","contentUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg","width":156,"height":53,"caption":"Cancer Research Institute"},"image":{"@id":"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/"}}]}},"fimg_url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/headshot-zach-earley-v2.webp","_links":{"self":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/cri_scientists\/35572","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/cri_scientists"}],"about":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/types\/cri_scientists"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/media\/35583"}],"wp:attachment":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/media?parent=35572"}],"wp:term":[{"taxonomy":"tax_cancer_type","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_cancer_type?post=35572"},{"taxonomy":"tax_grant_type","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_grant_type?post=35572"},{"taxonomy":"tax_award_year","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_award_year?post=35572"},{"taxonomy":"tax_institutions","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_institutions?post=35572"},{"taxonomy":"tax_location_states","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_location_states?post=35572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}