{"id":32153,"date":"2024-09-05T13:38:41","date_gmt":"2024-09-05T17:38:41","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=32153"},"modified":"2024-09-18T10:30:01","modified_gmt":"2024-09-18T14:30:01","slug":"julio-delgado-md","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/julio-delgado-md","title":{"rendered":"Julio Delgado, MD"},"content":{"rendered":"\n<p>Richter&#8217;s Transformation Syndrome (RT) is a grave complication of chronic lymphocytic leukemia (CLL), leading to aggressive lymphoma and poor patient outcomes. Current treatments, including R-CHOP therapy and hematopoietic cell transplantation, offer limited success, resulting in frequent relapses. Innovative strategies are urgently needed to improve survival prospects.&nbsp;&nbsp;<\/p>\n\n\n\n<p>Chimeric antigen receptor T cells (CAR T), particularly CART19 targeting CD19, have shown promise in B cell malignancies but are not effective for RT patients. In previous clinical studies, Dr. Delgado\u2019s ARI-0001 CAR T product achieved an 82 percent response rate but exhibited CD19-negative relapses. To address this, a novel dual CAR T cell, ARI-0003, targeting CD19 and CD269 (BCMA), was developed. This approach capitalizes on co-expression of CD19 and CD269 in lymphoma and overcomes CD19 antigenic loss. \u00a0<\/p>\n\n\n\n<p>Preclinical data demonstrated the superiority of ARI-0003 in eradicating RT cells. Therefore, a single-arm pilot trial is proposed to assess the safety and efficacy of ARI-0003 in adult patients with refractory RT. The study aims to provide a durable response and potentially a curative option for patients with high unmet medical needs, addressing the formidable challenge of Richter&#8217;s transformation and improving patient outcomes in this challenging disease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>RICHARDIII: A pilot study on the use of ARI-0003 cells (dual anti-CD19\/CD269 chimeric antigen receptor T cells) for patients with relapsed\/refractory Richter&#8217;s transformation<\/strong><\/h3>\n\n\n\n<p><strong>Institut d&#8217;Investigacions Biom\u00e8diques August Pi i Sunyer (<\/strong>Spain) | Lymphoma | 2024<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Richter&#8217;s Transformation Syndrome (RT) is a grave complication of chronic lymphocytic leukemia (CLL), leading to aggressive lymphoma and poor patient outcomes. Current treatments, including R-CHOP therapy and hematopoietic cell transplantation, offer limited [&hellip;]<\/p>\n","protected":false},"featured_media":32400,"template":"","tax_cancer_type":[355],"tax_grant_type":[725],"tax_award_year":[741],"tax_institutions":[775],"tax_location_states":[503],"class_list":["post-32153","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Clinical Innovator","quote":"","scientist_last_name":"Delgado","show_on_landing":false,"scientist_publish_until":"20280831"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Julio Delgado, MD - Cancer Research Institute<\/title>\n<meta name=\"description\" content=\"Dr. Delgado&#039;s study aims to provide a durable response and potentially a curative option for patients with high unmet medical needs, addressing the formidable challenge of Richter&#039;s transformation and improving lymphoma patient outcomes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/julio-delgado-md\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Julio Delgado, MD - 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