{"id":32104,"date":"2024-08-09T17:30:22","date_gmt":"2024-08-09T21:30:22","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=32104"},"modified":"2024-11-27T13:03:58","modified_gmt":"2024-11-27T18:03:58","slug":"matija-snuderl-md","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/matija-snuderl-md","title":{"rendered":"Matija Snuderl, MD"},"content":{"rendered":"\n<p>Chordomas are rare tumors arising from the clivus or sacrum. Chordomas are characterized by low mutational burden and lack of recurrent molecular drivers. Current therapies include aggressive surgery and radiation; however, adjuvant therapies are lacking and response to immunotherapy is low. Alternative immunotherapy strategies include developing tumor-specific chimeric antigen receptor (CAR) T cells. However, nuclear cancer specific oncoproteins are accessible to the immune system through the presentation of peptides on the major histocompatibility complex (MHC). Chordomas arise from notochordal tissue and express genes that show low or no expression in other tissues. <\/p>\n\n\n\n<p>Dr. Snuderl\u2019s multi-omic studies have shown that chordomas can be stratified into three major groups that vary in number of immune cells and using whole transcriptome and methylome he has identified potential chordoma-specific onco-peptides. In this proposal, Dr. Snuderl aims to explore onco-immunopeptidome and target it using synthetic chordoma-specific peptide-centric (PC) CARs, while avoiding toxicity of targeting normal tissues.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Developing peptide-centric CARs for therapy of chordoma<\/strong><\/h3>\n\n\n\n<p>New York University School of Medicine | Sarcoma | 2024<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chordomas are rare tumors arising from the clivus or sacrum. Chordomas are characterized by low mutational burden and lack of recurrent molecular drivers. Current therapies include aggressive surgery and radiation; however, adjuvant [&hellip;]<\/p>\n","protected":false},"featured_media":32105,"template":"","tax_cancer_type":[363,349],"tax_grant_type":[485],"tax_award_year":[741],"tax_institutions":[628],"tax_location_states":[494],"class_list":["post-32104","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI-Chordoma Foundation CLIP Investigator","quote":"","scientist_last_name":"Snuderl","show_on_landing":true,"scientist_publish_until":"20280831"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Matija Snuderl, MD - Cancer Research Institute<\/title>\n<meta name=\"description\" content=\"Dr. Snuderl aims to explore onco-immunopeptidome and target it using synthetic chordoma-specific peptide-centric CARs, while avoidingtoxicity of targeting normal tissues.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Matija Snuderl, MD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"Dr. Snuderl aims to explore onco-immunopeptidome and target it using synthetic chordoma-specific peptide-centric CARs, while avoidingtoxicity of targeting normal tissues.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md\" \/>\n<meta property=\"og:site_name\" content=\"Cancer Research Institute\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-27T18:03:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/08\/snuderl-matija.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"1200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md\",\"url\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md\",\"name\":\"Matija Snuderl, MD - Cancer Research Institute\",\"isPartOf\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/08\/snuderl-matija.jpg\",\"datePublished\":\"2024-08-09T21:30:22+00:00\",\"dateModified\":\"2024-11-27T18:03:58+00:00\",\"description\":\"Dr. Snuderl aims to explore onco-immunopeptidome and target it using synthetic chordoma-specific peptide-centric CARs, while avoidingtoxicity of targeting normal tissues.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md#primaryimage\",\"url\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/08\/snuderl-matija.jpg\",\"contentUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/08\/snuderl-matija.jpg\",\"width\":1200,\"height\":1200},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.cancerresearch.org\/es\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Matija Snuderl, MD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.cancerresearch.org\/#website\",\"url\":\"https:\/\/www.cancerresearch.org\/\",\"name\":\"Cancer Research Institute\",\"description\":\"For a World Immune to Cancer\",\"publisher\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.cancerresearch.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.cancerresearch.org\/#organization\",\"name\":\"Cancer Research Institute\",\"url\":\"https:\/\/www.cancerresearch.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg\",\"contentUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg\",\"width\":156,\"height\":53,\"caption\":\"Cancer Research Institute\"},\"image\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Matija Snuderl, MD - Cancer Research Institute","description":"Dr. Snuderl aims to explore onco-immunopeptidome and target it using synthetic chordoma-specific peptide-centric CARs, while avoidingtoxicity of targeting normal tissues.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md","og_locale":"es_ES","og_type":"article","og_title":"Matija Snuderl, MD - Cancer Research Institute","og_description":"Dr. Snuderl aims to explore onco-immunopeptidome and target it using synthetic chordoma-specific peptide-centric CARs, while avoidingtoxicity of targeting normal tissues.","og_url":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md","og_site_name":"Cancer Research Institute","article_modified_time":"2024-11-27T18:03:58+00:00","og_image":[{"width":1200,"height":1200,"url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/08\/snuderl-matija.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Tiempo de lectura":"1 minuto"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md","url":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md","name":"Matija Snuderl, MD - Cancer Research Institute","isPartOf":{"@id":"https:\/\/www.cancerresearch.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md#primaryimage"},"image":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md#primaryimage"},"thumbnailUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/08\/snuderl-matija.jpg","datePublished":"2024-08-09T21:30:22+00:00","dateModified":"2024-11-27T18:03:58+00:00","description":"Dr. Snuderl aims to explore onco-immunopeptidome and target it using synthetic chordoma-specific peptide-centric CARs, while avoidingtoxicity of targeting normal tissues.","breadcrumb":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md"]}]},{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md#primaryimage","url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/08\/snuderl-matija.jpg","contentUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/08\/snuderl-matija.jpg","width":1200,"height":1200},{"@type":"BreadcrumbList","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/matija-snuderl-md#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.cancerresearch.org\/es"},{"@type":"ListItem","position":2,"name":"Matija Snuderl, MD"}]},{"@type":"WebSite","@id":"https:\/\/www.cancerresearch.org\/#website","url":"https:\/\/www.cancerresearch.org\/","name":"Cancer Research Institute","description":"For a World Immune to Cancer","publisher":{"@id":"https:\/\/www.cancerresearch.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.cancerresearch.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/www.cancerresearch.org\/#organization","name":"Cancer Research Institute","url":"https:\/\/www.cancerresearch.org\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/","url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg","contentUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg","width":156,"height":53,"caption":"Cancer Research Institute"},"image":{"@id":"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/"}}]}},"fimg_url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/08\/snuderl-matija.jpg","_links":{"self":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/cri_scientists\/32104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/cri_scientists"}],"about":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/types\/cri_scientists"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/media\/32105"}],"wp:attachment":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/media?parent=32104"}],"wp:term":[{"taxonomy":"tax_cancer_type","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_cancer_type?post=32104"},{"taxonomy":"tax_grant_type","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_grant_type?post=32104"},{"taxonomy":"tax_award_year","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_award_year?post=32104"},{"taxonomy":"tax_institutions","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_institutions?post=32104"},{"taxonomy":"tax_location_states","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_location_states?post=32104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}