{"id":32098,"date":"2024-08-09T17:52:08","date_gmt":"2024-08-09T21:52:08","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=32098"},"modified":"2024-08-25T19:51:57","modified_gmt":"2024-08-25T23:51:57","slug":"xue-han-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/xue-han-phd","title":{"rendered":"Xue Han, PhD"},"content":{"rendered":"\n<p>In response to the limited treatment efficacy and high relapse rates in acute myeloid leukemia (AML), Dr. Han\u2019s project explores the role of the immune checkpoint molecule, programmed death-1 homolog (PD-1H, also called VISTA), in the AML microenvironment. <\/p>\n\n\n\n<p>Recognized for its unique elevated expression in AML compared to other immune checkpoint molecules, Dr. Han\u2019s study aims to unravel the impact of PD-1H on AML progression and immune suppression. The proposal includes three specific aims: (1) the use of a primary mouse AML model with CRISPR-Cas9 mediated PD-1H knockout to assess its influence on disease progression and immune dynamics, (2) to explore PD-1H\u2019s role in different immune cells within the AML microenvironment using conditional knockout mice, focusing on myeloid and T cells, and (3) to evaluate the therapeutic potential of PD-1H blockade, including its combination with other immunotherapies, in AML mouse models. <\/p>\n\n\n\n<p>This study is positioned to provide novel insights into the immunological aspects of AML and pave the way for innovative, more effective immunotherapeutic strategies for this malignancy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Advancing acute myeloid leukemia immunotherapy through PD-1H (VISTA) pathway interception<\/strong><\/h3>\n\n\n\n<p>Ohio State University | Leukemia | 2024<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In response to the limited treatment efficacy and high relapse rates in acute myeloid leukemia (AML), Dr. Han\u2019s project explores the role of the immune checkpoint molecule, programmed death-1 homolog (PD-1H, also [&hellip;]<\/p>\n","protected":false},"featured_media":32099,"template":"","tax_cancer_type":[358],"tax_grant_type":[485],"tax_award_year":[741],"tax_institutions":[773],"tax_location_states":[597],"class_list":["post-32098","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI CLIP Investigator","quote":"CRI's CLIP grant will support our research to deepen the understanding of AML's immunosuppressive microenvironment and to lay a scientific groundwork for innovative immunotherapies for AML treatment.","scientist_last_name":"Han","show_on_landing":true,"scientist_publish_until":"20280831"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - 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