{"id":30916,"date":"2024-01-19T17:56:57","date_gmt":"2024-01-19T22:56:57","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=30916"},"modified":"2024-01-19T17:56:59","modified_gmt":"2024-01-19T22:56:59","slug":"luke-postoak-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/luke-postoak-phd","title":{"rendered":"Luke Postoak, PhD\u00a0"},"content":{"rendered":"\n<p>Dr. Luke Postoak is investigating the process of antigen cross-presentation, where dendritic cells degrade cancer cells to present their proteins to CD-8+ T cells, activating killer T cell activity. Previous research in his parent lab established that this process relies on a unique molecule\u2014WDFY4\u2014expressed solely on dendritic cells. Despite this knowledge, the role of WDFY4 in antigen cross-presentation remains unclear.&nbsp;<\/p>\n\n\n\n<p>Dr. Postoak&#8217;s hypothesis proposes that WDFY4 acts as a scaffold, directing the intracellular trafficking of tumor antigens and facilitating their presentation on the cell surface for CD8+ T cells. To explore this, he is conducting studies to identify other molecules near WDFY4 in dendritic cells, creating a list of WDFY4 partners. Subsequently, a functional test will be performed to screen and identify partners that regulate the cross-presentation process.&nbsp;<\/p>\n\n\n\n<p>The objective of his research is to enhance our understanding of the mechanisms underlying cross-presentation. Additionally, by identifying novel modulators of anti-tumor immunity through this process, Dr. Postoak&#8217;s work may unveil new therapeutic targets.&nbsp;<\/p>\n\n\n\n<p>Dr. Postoak is supported by the CRI Irvington Postdoctoral Fellowship\u00a0to Promote Racial Diversity.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p><strong>Wdfy4 in cross-presentation and immunity<\/strong>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Luke Postoak is investigating the process of antigen cross-presentation, where dendritic cells degrade cancer cells to present their proteins to CD-8+ T cells, activating killer T cell activity. Previous research in [&hellip;]<\/p>\n","protected":false},"featured_media":30945,"template":"","tax_cancer_type":[455],"tax_grant_type":[486],"tax_award_year":[480],"tax_institutions":[491],"tax_location_states":[492],"class_list":["post-30916","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI-Irvington Postdoctoral Fellow","quote":"","scientist_last_name":"Postoak","show_on_landing":false,"scientist_publish_until":"20270101"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Luke Postoak, PhD\u00a0 - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/luke-postoak-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Luke Postoak, PhD\u00a0 - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"Dr. Luke Postoak is investigating the process of antigen cross-presentation, where dendritic cells degrade cancer cells to present their proteins to CD-8+ T cells, activating killer T cell activity. 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