{"id":30910,"date":"2024-01-19T16:25:49","date_gmt":"2024-01-19T21:25:49","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=30910"},"modified":"2024-09-26T10:08:39","modified_gmt":"2024-09-26T14:08:39","slug":"jing-zhang-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/jing-zhang-phd","title":{"rendered":"Jing Zhang, PhD"},"content":{"rendered":"\n<p>Dr. Jing Zhang is exploring a novel cancer treatment called anti-PDL1\/IL-15 (I) that aims to increase response to the immune checkpoint blockade anti-PDL1 alone, which benefits only 12 of U.S. cancer patients. She recently discovered a new tumor suppression pathway involving cytotoxic tissue-resident type 1 innate lymphocytes (ICL1) that play a role in a cancer\u2019s resistance to immune checkpoint blockade (ICB). The immune cytokine IL-15 regulates ICL1 responses, but the toxicity of recombinant IL-15 limits its usability.&nbsp;<\/p>\n\n\n\n<p>To overcome this limitation, Dr. Zhang developed a non-toxic therapeutic combination, anti-PD-L1\/IL-15 (I), which specifically targets tumors. This treatment successfully expanded ILC1s in aggressive liver cancer models and prevented subsequent tumor development in mice. Dr. Zhang is now focused on understanding how the anti-PD-L1\/IL-15 (I) therapy works and how it can sustain ICL1 responses to effectively combat tumor recurrence. Her study aims to provide the mechanism of action for ICL1-targeted immunotherapy, offering insights into this novel immunosurveillance response and guiding the development of anti-PD-L1\/IL-15 (I) for cancers resistant to ICB therapies.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<p><strong>Trained immunity in type I innate lymphoid cell (ILC1)-targeted cancer immunotherapy<\/strong><\/p>\n\n\n\n<p>Memorial Sloan Kettering Cancer Center | Liver Cancer | 2023<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Jing Zhang is exploring a novel cancer treatment called anti-PDL1\/IL-15 (I) that aims to increase response to the immune checkpoint blockade anti-PDL1 alone, which benefits only 12 of U.S. cancer patients. [&hellip;]<\/p>\n","protected":false},"featured_media":30911,"template":"","tax_cancer_type":[357],"tax_grant_type":[486],"tax_award_year":[480],"tax_institutions":[493],"tax_location_states":[494],"class_list":["post-30910","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI-Irvington Postdoctoral Fellow","quote":"","scientist_last_name":"Zhang","show_on_landing":false,"scientist_publish_until":"20260228"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Jing Zhang, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jing Zhang, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"Dr. Jing Zhang is exploring a novel cancer treatment called anti-PDL1\/IL-15 (I) that aims to increase response to the immune checkpoint blockade anti-PDL1 alone, which benefits only 12 of U.S. cancer patients. [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd\" \/>\n<meta property=\"og:site_name\" content=\"Cancer Research Institute\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-26T14:08:39+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/01\/Zhang-Jing-1.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"980\" \/>\n\t<meta property=\"og:image:height\" content=\"1307\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd\",\"url\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd\",\"name\":\"Jing Zhang, PhD - Cancer Research Institute\",\"isPartOf\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/01\/Zhang-Jing-1.jpeg\",\"datePublished\":\"2024-01-19T21:25:49+00:00\",\"dateModified\":\"2024-09-26T14:08:39+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd#primaryimage\",\"url\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/01\/Zhang-Jing-1.jpeg\",\"contentUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/01\/Zhang-Jing-1.jpeg\",\"width\":980,\"height\":1307,\"caption\":\"rpt\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.cancerresearch.org\/es\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Jing Zhang, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.cancerresearch.org\/#website\",\"url\":\"https:\/\/www.cancerresearch.org\/\",\"name\":\"Cancer Research Institute\",\"description\":\"For a World Immune to Cancer\",\"publisher\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.cancerresearch.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.cancerresearch.org\/#organization\",\"name\":\"Cancer Research Institute\",\"url\":\"https:\/\/www.cancerresearch.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg\",\"contentUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg\",\"width\":156,\"height\":53,\"caption\":\"Cancer Research Institute\"},\"image\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Jing Zhang, PhD - Cancer Research Institute","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd","og_locale":"es_ES","og_type":"article","og_title":"Jing Zhang, PhD - Cancer Research Institute","og_description":"Dr. Jing Zhang is exploring a novel cancer treatment called anti-PDL1\/IL-15 (I) that aims to increase response to the immune checkpoint blockade anti-PDL1 alone, which benefits only 12 of U.S. cancer patients. [&hellip;]","og_url":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd","og_site_name":"Cancer Research Institute","article_modified_time":"2024-09-26T14:08:39+00:00","og_image":[{"width":980,"height":1307,"url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/01\/Zhang-Jing-1.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd","url":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd","name":"Jing Zhang, PhD - Cancer Research Institute","isPartOf":{"@id":"https:\/\/www.cancerresearch.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd#primaryimage"},"image":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd#primaryimage"},"thumbnailUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/01\/Zhang-Jing-1.jpeg","datePublished":"2024-01-19T21:25:49+00:00","dateModified":"2024-09-26T14:08:39+00:00","breadcrumb":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd"]}]},{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd#primaryimage","url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/01\/Zhang-Jing-1.jpeg","contentUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/01\/Zhang-Jing-1.jpeg","width":980,"height":1307,"caption":"rpt"},{"@type":"BreadcrumbList","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jing-zhang-phd#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.cancerresearch.org\/es"},{"@type":"ListItem","position":2,"name":"Jing Zhang, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.cancerresearch.org\/#website","url":"https:\/\/www.cancerresearch.org\/","name":"Cancer Research Institute","description":"For a World Immune to Cancer","publisher":{"@id":"https:\/\/www.cancerresearch.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.cancerresearch.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/www.cancerresearch.org\/#organization","name":"Cancer Research Institute","url":"https:\/\/www.cancerresearch.org\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/","url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg","contentUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg","width":156,"height":53,"caption":"Cancer Research Institute"},"image":{"@id":"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/"}}]}},"fimg_url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2024\/01\/Zhang-Jing-1.jpeg","_links":{"self":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/cri_scientists\/30910","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/cri_scientists"}],"about":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/types\/cri_scientists"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/media\/30911"}],"wp:attachment":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/media?parent=30910"}],"wp:term":[{"taxonomy":"tax_cancer_type","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_cancer_type?post=30910"},{"taxonomy":"tax_grant_type","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_grant_type?post=30910"},{"taxonomy":"tax_award_year","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_award_year?post=30910"},{"taxonomy":"tax_institutions","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_institutions?post=30910"},{"taxonomy":"tax_location_states","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_location_states?post=30910"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}