{"id":29804,"date":"2023-08-24T15:37:11","date_gmt":"2023-08-24T19:37:11","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=29804"},"modified":"2023-08-24T15:50:01","modified_gmt":"2023-08-24T19:50:01","slug":"courtney-a-matson-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/courtney-a-matson-phd","title":{"rendered":"Courtney A. Matson, PhD"},"content":{"rendered":"\n<p>CD8 T cells are critical components of anti-tumor immunity through their release of cytokines and direct killing of malignant cells. Unfortunately, cancer can develop in tissues with low T cell surveillance and tumors diminish T cell responses via chronic stimulation-induced exhaustion. Dr. Matson and colleagues developed a model in which CD8 T cells were repeatedly stimulated over time while still maintaining function. When these \u2018superboosted\u2019 cells are exposed to chronic stimulation, they survive and function much longer than other T cells, suggesting adaptations to subvert exhaustion. Moreover, superboosted T cells recirculate through different tissues of the body in the absence of infection; a skill that other T cells typically lack. Dr. Matson\u2019s proposal will explore two unique programs of superboosted T cells: their ability to maintain function under chronic stimulation and their ability to recirculate through tissues. First, she will dissect molecular programs that resist cancer-associated exhaustion, identifying potential novel strategies for engineering adoptive cell therapies to generate durable T cell function. Second, she will evaluate the receptors necessary for organ and tumor migration to provide strategies for targeting T cells to specific areas in the body. Investigating these adaptations of superboosted T cells provides a unique opportunity to discover cellular mechanisms for maintaining T cell function and recirculation, two hurdles successful immunotherapy must overcome.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Defining exhaustion resistance and global surveillance programs in T cells<strong><strong><strong><strong><strong> <\/strong><\/strong> <\/strong><\/strong><\/strong>&nbsp;<\/strong><\/h3>\n\n\n\n<p>University of Minnesota | All Cancers | 2023 | David Masopust, PhD<\/p>\n","protected":false},"excerpt":{"rendered":"<p>CD8 T cells are critical components of anti-tumor immunity through their release of cytokines and direct killing of malignant cells. Unfortunately, cancer can develop in tissues with low T cell surveillance and [&hellip;]<\/p>\n","protected":false},"featured_media":29805,"template":"","tax_cancer_type":[455],"tax_grant_type":[486],"tax_award_year":[480],"tax_institutions":[586],"tax_location_states":[532],"class_list":["post-29804","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"Eugene V. Weissman Fellow","quote":"","scientist_last_name":"Matson","show_on_landing":true,"scientist_publish_until":"20260731"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Courtney A. 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