{"id":29617,"date":"2023-08-09T10:41:22","date_gmt":"2023-08-09T14:41:22","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=29617"},"modified":"2023-08-14T14:52:39","modified_gmt":"2023-08-14T18:52:39","slug":"josep-maria-m-piulats-md-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/josep-maria-m-piulats-md-phd","title":{"rendered":"Josep Maria M. Piulats, MD, PhD"},"content":{"rendered":"\n<p>Dr. Piulats\u2019s project is focused on the development of a new cellular therapy against uveal melanoma (UM). Uveal melanoma (UM) is the most common and deadly ocular malignancy in adults with approximately 50% of patients becoming metastatic. Until recently, the median overall survival (OS) was less than 12 months. Two immunotherapies based on tumor infiltrating cells (TILs) infusion or Tebentafusp, a molecule recognizing the antigen gp100, have shown an improvement in OS. Regrettably, Tebentafusp can only be used in 40% of patients expressing a particular haplotype and must be administered for the rest of their lives. TILs infusion is an expensive, toxic, and long procedure that requires removal of a metastatic lesion and more than a month of TIL manufacturing, thus limiting the patients that can benefit from this therapy. &nbsp;<\/p>\n\n\n\n<p>Dr. Piulats has found memory T cells from peripheral blood recognizing the mutated epitopes of the two typical driver mutations of UM GNAQ and GNA11, in patients with UM. Dr. Piulats aims to characterize the reactive T cell receptors (TCR) against these epitopes, the associated haplotype and minimal peptide bound to them to develop a novel cellular therapy product that would present several advantages: &nbsp;(1) It targets &nbsp;the driver mutation associated to UM, avoiding to some extent resistance mechanisms and being specific for tumor cells (2) it is &nbsp;an off-the- shelf product useful for all patients sharing the same haplotype that stands to reduce the overall cost and shorten the time to treatment to 2 weeks; (3) it is a single dose therapy, and (4) it can be combined with other therapies to increase efficacy. &nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong><strong><strong>Generation of personalized TCR therapy against GNAQ\/11 Q209L mutations in Uveal melanoma <\/strong><\/strong><\/strong>&nbsp;<\/strong><\/h3>\n\n\n\n<p>Fundacio Institut D&#8217;Investigacio Biomedica de Bellvitge, L&#8217;Hospitalet del Llobregat&nbsp;| Melanoma | 2023<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Piulats\u2019s project is focused on the development of a new cellular therapy against uveal melanoma (UM). Uveal melanoma (UM) is the most common and deadly ocular malignancy in adults with approximately [&hellip;]<\/p>\n","protected":false},"featured_media":29596,"template":"","tax_cancer_type":[354],"tax_grant_type":[485],"tax_award_year":[480],"tax_institutions":[724],"tax_location_states":[503],"class_list":["post-29617","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI CLIP Investigator","quote":"","scientist_last_name":"Piulats","show_on_landing":true,"scientist_publish_until":"20260731"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Josep Maria M. 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