{"id":29424,"date":"2023-07-17T14:20:55","date_gmt":"2023-07-17T18:20:55","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=29424"},"modified":"2024-08-14T12:03:06","modified_gmt":"2024-08-14T16:03:06","slug":"sidi-chen-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/sidi-chen-phd","title":{"rendered":"Sidi Chen, PhD"},"content":{"rendered":"\n<p>Dr. Sidi Chen seeks to address fundamental problems in cancer genetics and immunity, and to leverage those insights to develop next-generation immunotherapies.<\/p>\n\n\n\n<p>Working at the intersection of these two emerging fields, Dr. Chen has pioneered the concept \u201cgenome engineering <em>for<\/em>, <em>of<\/em>, and <em>as<\/em> immunotherapy\u201d\u2014as in, applying high-throughput CRISPR screening technologies to discover new targets <em>for<\/em> immunotherapy, directly editing the genomes of T cells to create better versions <em>of <\/em>cellular immunotherapies like CAR T cells, and harnessing the genome engineering machinery itself to re-program immune cells <em>as<\/em> novel immunotherapy agents. Overall, Dr. Chen\u2019s lab is focused on uncovering novel insights into cancer by taking advantage of diverse disciplines across genetics, immunobiology, and systems biology to transform the development of new immunotherapies. Over the next five years, his goal is to advance both fundamental research, cancer therapeutic candidate development, and translational studies. If successfully translated into the clinic, these therapies could benefit a broad range of patient populations across multiple cancer types.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Genome engineering for, of, and as immunotherapy<\/strong><\/h3>\n\n\n\n<p>Yale University | All Cancers | 2023<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Systematic identification of druggable targets for enhancement of PD-1 checkpoint blockade therapy in melanoma<\/strong><\/h3>\n\n\n\n<p>Yale University | Melanoma | 2017<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Sidi Chen seeks to address fundamental problems in cancer genetics and immunity, and to leverage those insights to develop next-generation immunotherapies. Working at the intersection of these two emerging fields, Dr. [&hellip;]<\/p>\n","protected":false},"featured_media":29410,"template":"","tax_cancer_type":[455],"tax_grant_type":[482],"tax_award_year":[480],"tax_institutions":[498],"tax_location_states":[499],"class_list":["post-29424","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Lloyd J. Old STAR","quote":"My vision is to understand the fundamental problems in the genetics and immunity of cancer, and to develop next-generation therapeutics.","scientist_last_name":"Chen","show_on_landing":false,"scientist_publish_until":"20280630"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Sidi Chen, PhD - Cancer Research Institute<\/title>\n<meta name=\"description\" content=\"Dr. Sidi Chen seeks to address fundamental problems in cancer genetics and immunity, and to leverage those insights to develop next-generation immunotherapies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/sidi-chen-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sidi Chen, PhD - 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