{"id":29363,"date":"2023-07-10T13:24:07","date_gmt":"2023-07-10T17:24:07","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=29363"},"modified":"2023-07-10T13:24:08","modified_gmt":"2023-07-10T17:24:08","slug":"aravindabharathi-ramakrishnan-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/aravindabharathi-ramakrishnan-phd","title":{"rendered":"Aravindabharathi Ramakrishnan, PhD"},"content":{"rendered":"\n<p>Dr. Aravindabharathi Ramakrishnan is exploring how cancers exploit the TGF-\u03b21 pathway for protection, so that he can develop strategies to overcome its effects and improve the immune system\u2019s ability to eliminate tumors.<\/p>\n\n\n\n<p>TGF-\u03b21 is a signaling protein that suppresses the activity of immune cells and protects us against excessive autoimmune reactions. Unfortunately, cancer can co-opt this pathway to shield tumors from our immune system. Blocking TGF-\u03b21 could therefore be an important intervention that allows cancer cells to be recognized and targeted by our immune systems, but it must be done in a cancer-specific way to reduce the risk of autoimmune disease. One potential way to block its activity could be targeting the activation of TGF-\u03b21 (from its inert precursor \u201cproTGF-\u03b21). Specifically, Dr. Ramakrishnan is investigating how a protein called \u237aV\u03b28 activates proTGF-\u03b21 in cancer through a force-independent mechanism. Through his CRI fellowship, he hopes to identify the structural features unique to \u237aV\u03b28 that allow force-independent activation of proTGF-\u03b21 and as well as other molecules that assist in this process. Overall, his research seeks to shed light on these TGB-\u03b21-related mechanisms that allow cancer to escape the immune system in order to design ways to disrupt its effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Mechanisms of force-independent activation of TGF-\u03b21 by integrin \u237aV\u03b28<strong><br><\/strong><\/strong><\/h3>\n\n\n\n<p>Boston Children&#8217;s Hospital | All Cancers| 2023 | Timothy Springer, PhD<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Aravindabharathi Ramakrishnan is exploring how cancers exploit the TGF-\u03b21 pathway for protection, so that he can develop strategies to overcome its effects and improve the immune system\u2019s ability to eliminate tumors. [&hellip;]<\/p>\n","protected":false},"featured_media":29364,"template":"","tax_cancer_type":[455],"tax_grant_type":[486],"tax_award_year":[480],"tax_institutions":[489],"tax_location_states":[490],"class_list":["post-29363","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Postdoctoral Fellow","quote":"As a CRI Fellow, I am studying the mechanism by which integrin \u237aV\u03b28 converts the TGF-\r\n\u03b21 molecule from its active to its inactive form.","scientist_last_name":"Ramakrishnan","show_on_landing":true,"scientist_publish_until":"20240630"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Aravindabharathi Ramakrishnan<\/title>\n<meta name=\"description\" content=\"Dr. Aravindabharathi Ramakrishnan is exploring how cancers exploit the TGF-\u03b21 pathway for protection, so that he can develop strategies to overcome its 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