{"id":29360,"date":"2023-07-10T13:10:17","date_gmt":"2023-07-10T17:10:17","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=29360"},"modified":"2023-07-10T13:10:18","modified_gmt":"2023-07-10T17:10:18","slug":"randall-s-carpenter-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/randall-s-carpenter-phd","title":{"rendered":"Randall S. Carpenter, PhD"},"content":{"rendered":"\n<p>Dr. Randall S. Carpenter is exploring how a potential link between nerves and reactive oxygen species (ROS) influences the immune system\u2019s ability to eliminate leukemia cells.<\/p>\n\n\n\n<p>Acute myeloid leukemia (AML) is a devastating blood cancer that affects 20,000 people every year in the U.S. and causes approximately 12,000 deaths. The standard of care for AML patients is chemotherapy and blood stem cell transplantation. However, the 5-year survival rate is less than 25% due to changes in bone marrow that promote the survival of leukemic stem cells that can reactivate years after the initial disease. One change in the bone marrow during leukemia is the loss of sympathetic nerves, a process that accelerates disease and hastens death in mice. While sympathetic nerves are known to be lost during leukemia, it remains unknown how the loss of nerve signals limits the development of leukemia.<\/p>\n\n\n\n<p>Dr. Carpenter hypothesizes that a loss of nerve signals contributes to excess production of reactive oxygen species (ROS), small molecules produced by immune cells in the bone marrow. Elevated ROS levels, in turn, then impair the immune response against leukemia. Overall, he&nbsp; envisions that targeting this neuro-immune communication may complement existing therapies to improve the immune system\u2019s ability to search out leukemic stem cells in the bone marrow, ultimately preventing relapse and improving patient outcomes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong>Regulation of innate and adaptive immune function in the leukemic microenvironment by sympathetic nerves and reactive oxygen species<br><\/strong><\/strong><\/h3>\n\n\n\n<p>Albert Einstein College of Medicine | Leukemia | 2023 | Maria Maryanovich, PhD<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Randall S. Carpenter is exploring how a potential link between nerves and reactive oxygen species (ROS) influences the immune system\u2019s ability to eliminate leukemia cells. Acute myeloid leukemia (AML) is a [&hellip;]<\/p>\n","protected":false},"featured_media":29361,"template":"","tax_cancer_type":[358],"tax_grant_type":[486],"tax_award_year":[480],"tax_institutions":[600],"tax_location_states":[494],"class_list":["post-29360","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Postdoctoral Fellow","quote":"My research is investigating the bi-directional communication between the central nervous system and peripheral immune system in health and disease.","scientist_last_name":"Carpenter","show_on_landing":true,"scientist_publish_until":"20240630"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Randall S. Carpenter<\/title>\n<meta name=\"description\" content=\"Dr. Randall S. Carpenter is exploring how a potential link between nerves and reactive oxygen species (ROS) influences the immune system\u2019s ability to eliminate leukemia cells.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Randall S. Carpenter\" \/>\n<meta property=\"og:description\" content=\"Dr. Randall S. Carpenter is exploring how a potential link between nerves and reactive oxygen species (ROS) influences the immune system\u2019s ability to eliminate leukemia cells.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd\" \/>\n<meta property=\"og:site_name\" content=\"Cancer Research Institute\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-10T17:10:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2023\/07\/Carpenter.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd\",\"url\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd\",\"name\":\"Randall S. Carpenter\",\"isPartOf\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2023\/07\/Carpenter.jpeg\",\"datePublished\":\"2023-07-10T17:10:17+00:00\",\"dateModified\":\"2023-07-10T17:10:18+00:00\",\"description\":\"Dr. Randall S. Carpenter is exploring how a potential link between nerves and reactive oxygen species (ROS) influences the immune system\u2019s ability to eliminate leukemia cells.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd#primaryimage\",\"url\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2023\/07\/Carpenter.jpeg\",\"contentUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2023\/07\/Carpenter.jpeg\",\"width\":800,\"height\":800,\"caption\":\"Randall S. Carpenter\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.cancerresearch.org\/es\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Randall S. Carpenter, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.cancerresearch.org\/#website\",\"url\":\"https:\/\/www.cancerresearch.org\/\",\"name\":\"Cancer Research Institute\",\"description\":\"For a World Immune to Cancer\",\"publisher\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.cancerresearch.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.cancerresearch.org\/#organization\",\"name\":\"Cancer Research Institute\",\"url\":\"https:\/\/www.cancerresearch.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg\",\"contentUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg\",\"width\":156,\"height\":53,\"caption\":\"Cancer Research Institute\"},\"image\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Randall S. Carpenter","description":"Dr. Randall S. Carpenter is exploring how a potential link between nerves and reactive oxygen species (ROS) influences the immune system\u2019s ability to eliminate leukemia cells.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd","og_locale":"es_ES","og_type":"article","og_title":"Randall S. Carpenter","og_description":"Dr. Randall S. Carpenter is exploring how a potential link between nerves and reactive oxygen species (ROS) influences the immune system\u2019s ability to eliminate leukemia cells.","og_url":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd","og_site_name":"Cancer Research Institute","article_modified_time":"2023-07-10T17:10:18+00:00","og_image":[{"width":800,"height":800,"url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2023\/07\/Carpenter.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd","url":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd","name":"Randall S. Carpenter","isPartOf":{"@id":"https:\/\/www.cancerresearch.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd#primaryimage"},"image":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd#primaryimage"},"thumbnailUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2023\/07\/Carpenter.jpeg","datePublished":"2023-07-10T17:10:17+00:00","dateModified":"2023-07-10T17:10:18+00:00","description":"Dr. Randall S. Carpenter is exploring how a potential link between nerves and reactive oxygen species (ROS) influences the immune system\u2019s ability to eliminate leukemia cells.","breadcrumb":{"@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd"]}]},{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd#primaryimage","url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2023\/07\/Carpenter.jpeg","contentUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2023\/07\/Carpenter.jpeg","width":800,"height":800,"caption":"Randall S. Carpenter"},{"@type":"BreadcrumbList","@id":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/randall-s-carpenter-phd#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.cancerresearch.org\/es"},{"@type":"ListItem","position":2,"name":"Randall S. Carpenter, PhD"}]},{"@type":"WebSite","@id":"https:\/\/www.cancerresearch.org\/#website","url":"https:\/\/www.cancerresearch.org\/","name":"Cancer Research Institute","description":"For a World Immune to Cancer","publisher":{"@id":"https:\/\/www.cancerresearch.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.cancerresearch.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/www.cancerresearch.org\/#organization","name":"Cancer Research Institute","url":"https:\/\/www.cancerresearch.org\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/","url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg","contentUrl":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg","width":156,"height":53,"caption":"Cancer Research Institute"},"image":{"@id":"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/"}}]}},"fimg_url":"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2023\/07\/Carpenter.jpeg","_links":{"self":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/cri_scientists\/29360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/cri_scientists"}],"about":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/types\/cri_scientists"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/media\/29361"}],"wp:attachment":[{"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/media?parent=29360"}],"wp:term":[{"taxonomy":"tax_cancer_type","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_cancer_type?post=29360"},{"taxonomy":"tax_grant_type","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_grant_type?post=29360"},{"taxonomy":"tax_award_year","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_award_year?post=29360"},{"taxonomy":"tax_institutions","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_institutions?post=29360"},{"taxonomy":"tax_location_states","embeddable":true,"href":"https:\/\/www.cancerresearch.org\/es\/wp-json\/wp\/v2\/tax_location_states?post=29360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}