{"id":27447,"date":"2023-01-12T11:19:17","date_gmt":"2023-01-12T16:19:17","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=27447"},"modified":"2024-10-29T14:18:41","modified_gmt":"2024-10-29T18:18:41","slug":"chiara-falcomata-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/chiara-falcomata-phd","title":{"rendered":"Chiara Falcomat\u00e0, PhD"},"content":{"rendered":"\n<p>Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease that lacks efficient therapies. While immunotherapies have been shown to benefit several tumor entities, a major reason for their failure in PDAC is its immunosuppressive tumor microenvironment (TME), composed of pro-tumorigenic immune cells, such as macrophages, and lacking anti-tumorigenic ones, such as T cells. Cancer cells produce messengers that drive not only PDAC progression and treatment resistance, but also shape its TME composition. However, how PDAC cells orchestrate this cancer-protective environment is not known. Dr. Falcomat\u00e0 hypothesizes that PDAC cell-derived immune signals promote immunosuppression and immune evasion and that their targeting would be beneficial to unleash anti-tumor immunity. She will test if receptors expressed, and soluble factors secreted by PDAC cells act on recruitment and differentiation of pro-tumorigenic immune cells and exclude anti-tumorigenic ones. With the goal to mechanistically identify genes in PDAC cells controlling TME organization, driving tumor progression, and preventing immune-mediated tumor eradication, Dr. Falcomat\u00e0 will make use of Perturb-map. This technology enables her to alter the function of dozens of genes within a tumor with single-cell resolution and spatial architecture readouts, enabling the study of several genes\u2019 function in parallel. The outcome of these studies will (1) establish the function of hypothesis-selected PDAC-associated genes on tumor growth and immunity, (2) provide potential biomarkers for predicting response to immunotherapy, and importantly, (3) identify actionable therapeutic targets for enhancing anti-tumor immunity. The long-term goal is to translate these findings into effective therapies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><strong><strong><strong><strong>Identifying mechanisms of tumor immune composition control in pancreatic cancer<\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n<p>Icahn School of Medicine at Mount Sinai | Pancreatic Cancer | 2023 | Brian D. Brown, PhD<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease that lacks efficient therapies. While immunotherapies have been shown to benefit several tumor entities, a major reason for their failure in PDAC is its [&hellip;]<\/p>\n","protected":false},"featured_media":27594,"template":"","tax_cancer_type":[455,351],"tax_grant_type":[486],"tax_award_year":[480],"tax_institutions":[540],"tax_location_states":[494],"class_list":["post-27447","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"Postdoctoral Fellow","quote":"As a CRI-funded postdoctoral fellow, I will investigate factors controlling the composition, organization, and molecular state of pancreatic cancer tumor microenvironment.","scientist_last_name":"Falcomata","show_on_landing":true,"scientist_publish_until":"20260726"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Chiara Falcomat\u00e0, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/chiara-falcomata-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chiara Falcomat\u00e0, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease that lacks efficient therapies. 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