{"id":27399,"date":"2022-12-30T15:34:01","date_gmt":"2022-12-30T20:34:01","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=27399"},"modified":"2023-01-26T10:16:35","modified_gmt":"2023-01-26T15:16:35","slug":"jianhang-yin-ph-d","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/jianhang-yin-ph-d","title":{"rendered":"Jianhang Yin, PhD"},"content":{"rendered":"\n<p>CD40 signaling and downstream NF-\u03baB pathways play important roles in germinal center (GC) B cell development and differentiation. However, it remains to be elucidated whether higher MHC-peptide presented by GC B cells induces increased cumulative CD40 signaling strength. The first aim of Dr. Yin\u2019s proposal is to measure CD40 signaling strength by generating a novel NF-\u03baB pathway reporter mouse line. He will define how the strength of canonical and alternative NF-\u03baB pathways corresponds to different amounts of MHC-peptide presentation <em>in vivo<\/em> by multiple approaches. He will also determine whether NF-\u03baB signaling strength is associated with dark zone B cell recycling, memory B cell differentiation, and plasma cell differentiation.<br><br>The second aim of Dr. Yin\u2019s project is to define how TCR signaling strength is associated with the amount of CD40L on the cell surface available for GC B cells. Despite the observation that more MHC-peptide presented by GC B cells induces more CD40L mobilized on the Tfh cell surface, the underlying regulators involved in this process remain unclear. A genome-wide screening by CRISPR in a CD40L-GFP T cell line will be performed to identify factors controlling CD40L storage and transport. Taken together, these studies will improve our understanding of how GC B and T cells interact with and affect each other to drive the generation of high affinity antibody producing cells and memory B cells.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Defining the mechanism underlying helper T cell selection of high affinity B cells in germinal centers<\/h2>\n\n\n\n<p>All Cancers | University of California, San Francisco | 2023 | Jason Cyster, PhD<\/p>\n","protected":false},"excerpt":{"rendered":"<p>CD40 signaling and downstream NF-\u03baB pathways play important roles in germinal center (GC) B cell development and differentiation. However, it remains to be elucidated whether higher MHC-peptide presented by GC B cells [&hellip;]<\/p>\n","protected":false},"featured_media":27476,"template":"","tax_cancer_type":[455],"tax_grant_type":[486],"tax_award_year":[480],"tax_institutions":[500],"tax_location_states":[],"class_list":["post-27399","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"Postdoctoral Fellow","quote":"","scientist_last_name":"Yin","show_on_landing":true,"scientist_publish_until":"20260101"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Jianhang Yin, PhD - Cancer Research Institute<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jianhang-yin-ph-d\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Jianhang Yin, PhD - Cancer Research Institute\" \/>\n<meta property=\"og:description\" content=\"CD40 signaling and downstream NF-\u03baB pathways play important roles in germinal center (GC) B cell development and differentiation. However, it remains to be elucidated whether higher MHC-peptide presented by GC B cells [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jianhang-yin-ph-d\" \/>\n<meta property=\"og:site_name\" content=\"Cancer Research Institute\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-26T15:16:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2022\/12\/Yin-Jianhang-resized.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"440\" \/>\n\t<meta property=\"og:image:height\" content=\"441\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jianhang-yin-ph-d\",\"url\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jianhang-yin-ph-d\",\"name\":\"Jianhang Yin, PhD - Cancer Research Institute\",\"isPartOf\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jianhang-yin-ph-d#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jianhang-yin-ph-d#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2022\/12\/Yin-Jianhang-resized.jpg\",\"datePublished\":\"2022-12-30T20:34:01+00:00\",\"dateModified\":\"2023-01-26T15:16:35+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jianhang-yin-ph-d#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jianhang-yin-ph-d\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jianhang-yin-ph-d#primaryimage\",\"url\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2022\/12\/Yin-Jianhang-resized.jpg\",\"contentUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2022\/12\/Yin-Jianhang-resized.jpg\",\"width\":440,\"height\":441},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jianhang-yin-ph-d#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.cancerresearch.org\/es\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Jianhang Yin, PhD\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.cancerresearch.org\/#website\",\"url\":\"https:\/\/www.cancerresearch.org\/\",\"name\":\"Cancer Research Institute\",\"description\":\"For a World Immune to Cancer\",\"publisher\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.cancerresearch.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.cancerresearch.org\/#organization\",\"name\":\"Cancer Research Institute\",\"url\":\"https:\/\/www.cancerresearch.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg\",\"contentUrl\":\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/05\/logo-gradient.svg\",\"width\":156,\"height\":53,\"caption\":\"Cancer Research Institute\"},\"image\":{\"@id\":\"https:\/\/www.cancerresearch.org\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Jianhang Yin, PhD - Cancer Research Institute","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/jianhang-yin-ph-d","og_locale":"es_ES","og_type":"article","og_title":"Jianhang Yin, PhD - Cancer Research Institute","og_description":"CD40 signaling and downstream NF-\u03baB pathways play important roles in germinal center (GC) B cell development and differentiation. 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