Our immune system is designed to recognize and eliminate cancer cells through the same mechanisms as it would with invading pathogens. CD8+ T cells in particular recognize atypical cancer antigens presented on the surface of antigen presenting cells (APCs) that instruct them to destroy cancer cells. However, tumors have developed mechanisms to evade the immune system by \u201cturning off\u201d the CD8+ T cell attack. CD8+ T cells that invade the tumor are known to lose functionality and develop dysfunctional or \u201cexhausted\u201d phenotypes as tumors progress, thereby resulting in their inability to eliminate the tumor. The emergence of immunotherapies, which are designed to stop tumor cells from \u201cturning off\u201d CD8+ T cells, has made a significant impact in the cancer field. However, these therapies are only successful in a fraction of cancer patients and do not work for all cancer types. Thus, there is an urgent need for novel immunotherapy strategies. Dr. Hess’ work has identified molecules that mediate interactions between APCs and CD8+ T cells that decrease during tumor progression.<\/p>\n\n\n\n
In this proposal, Dr. Hess will test how modulation of these molecules impacts the anti-tumor functions of CD8+ T cells and will test two different therapeutic approaches to improve the interaction between APCs and CD8+ T cells using cell engineering and engineered nanoparticles. The goal is to understand how interaction with APCs regulate the functions of CD8+ T cells in cancer and to leverage this information to design novel therapeutic approaches that can be readily translated to the clinic.<\/p>\n\n\n\n
Dr. Hess is supported by the CRI Irvington Postdoctoral Fellowship\u00a0to Promote Racial Diversity.<\/p>\n\n\n\n
Brigham and Women\u2019s Hospital \/ Harvard Medical School | All Cancers | 2022 | Ana C. Anderson, Ph.D.<\/p>\n","protected":false},"excerpt":{"rendered":"
Our immune system is designed to recognize and eliminate cancer cells through the same mechanisms as it would with invading pathogens. CD8+ T cells in particular recognize atypical cancer antigens presented on […]<\/p>\n","protected":false},"featured_media":25840,"template":"","tax_cancer_type":[],"tax_grant_type":[486],"tax_award_year":[479],"tax_institutions":[649],"tax_location_states":[490],"class_list":["post-25563","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI-Bristol Myers Squibb Postdoctoral Fellow","quote":"The CRI Fellowship allows me to improve our knowledge of cell interactions in the tumor microenvironment that shape anti-tumor immunity and to identify next generation therapeutic approaches.","scientist_last_name":"Hess","show_on_landing":true,"scientist_publish_until":"20250630"},"yoast_head":"\n