{"id":24730,"date":"2022-09-19T20:17:47","date_gmt":"2022-09-20T00:17:47","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=24730"},"modified":"2023-01-24T00:30:05","modified_gmt":"2023-01-24T05:30:05","slug":"ivan-zanoni-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/ivan-zanoni-phd","title":{"rendered":"Ivan Zanoni, PhD"},"content":{"rendered":"\n<p>The immune system has evolved to protect against infectious viruses and bacteria, and to maintain tissue homeostasis. But in some instances the immune system can overreact and drive inflammation that leads to tissue damage or even cancer development.&nbsp;Phagocytes, such as neutrophils, play a&nbsp;central role in driving the immune activity and determining the outcome of responses.&nbsp;<br><br>Zanoni\u2019s team recently highlighted the importance of two factors\u2014type III interferons and oxidized lipid metabolites\u2014that are produced during inflammatory responses and regulate phagocyte functions and metabolism. Now, his research seeks to link metabolic changes to the expression of type III interferons, which act on tumor-associated neutrophils to alter their metabolism and promote the development of colorectal cancer. Specifically, he aims to<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>determine how type III&nbsp;interferons exert their pro-tumor functions in neutrophils,<\/li><li>establish how immunometabolic changes in the&nbsp;inflamed gut promote tumor formation, and<\/li><li>use newly identified phagocyte-related pathways to design therapeutic interventions against&nbsp;cancer.<\/li><\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Innate immune control of colorectal cancer<\/h3>\n\n\n\n<p>Boston Children\u2019s Hospital | Colorectal Cancer | 2021<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The immune system has evolved to protect against infectious viruses and bacteria, and to maintain tissue homeostasis. But in some instances the immune system can overreact and drive inflammation that leads to [&hellip;]<\/p>\n","protected":false},"featured_media":5129,"template":"","tax_cancer_type":[362],"tax_grant_type":[482],"tax_award_year":[478],"tax_institutions":[489],"tax_location_states":[490],"class_list":["post-24730","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Lloyd J. Old STAR","quote":"","scientist_last_name":"Zanoni","show_on_landing":true,"scientist_publish_until":"20260630"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ivan Zanoni, PhD<\/title>\n<meta name=\"description\" content=\"Dr. Zanoni aims to use newly identified phagocyte-related pathways to design therapeutic interventions against\u00a0cancer.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/ivan-zanoni-phd\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ivan Zanoni, PhD\" \/>\n<meta property=\"og:description\" content=\"Dr. Zanoni aims to use newly identified phagocyte-related pathways to design therapeutic interventions 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