{"id":24685,"date":"2022-09-19T20:17:34","date_gmt":"2022-09-20T00:17:34","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=24685"},"modified":"2025-12-15T15:45:07","modified_gmt":"2025-12-15T20:45:07","slug":"greg-m-delgoffe-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/greg-m-delgoffe-phd","title":{"rendered":"Greg M. Delgoffe, PhD"},"content":{"rendered":"\n<p>The landscape of cancer treatment has been fundamentally changed by advances in immunotherapy: bolstering or augmenting the body\u2019s own defenses to attack and eliminate cancer cells. While some patients experience remarkable responses to these immunotherapies, most will not benefit. This highlights a major gap in our understanding, namely that we do not fully understand how the immune system is regulated at the tumor site. Cancer cells must fuel their constant division, and as such become metabolically \u2018deregulated,\u2019 depleting the local environment of nutrients and oxygen.<\/p>\n\n\n\n<p>Dr. Delgoffe\u2019s lab is exploring the idea that this metabolic landscape might hinder immunotherapy, as T cells infiltrating the tumor can essentially be \u2018starved\u2019 of the fuel needed for their activity. By diving deeper into the interplay between metabolic stress and immune dysfunction in cancer, Delgoffe\u2019s team has found that while this nutrient dearth environment can suppress the function of healthy immune cells that may destroy tumors, other more dysfunctional types of immune cells can thrive in this altered state. He seeks to understand the precise metabolic pathways that support the survival of deleterious immune cells within tumors and develop metabolic reprogramming strategies that may function by eliminating these cells. Ultimately, he hopes the insights his team uncovers can pave the way for the development of improved cancer immunotherapy strategies that provide metabolic support to this revived immune response.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Reversing T Cell Dysfunction Through Metabolic Reprogramming<\/h3>\n\n\n\n<p>University of Pittsburgh School of Medicine | All Cancers | 2020<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The landscape of cancer treatment has been fundamentally changed by advances in immunotherapy: bolstering or augmenting the body\u2019s own defenses to attack and eliminate cancer cells. While some patients experience remarkable responses [&hellip;]<\/p>\n","protected":false},"featured_media":2720,"template":"","tax_cancer_type":[455],"tax_grant_type":[482],"tax_award_year":[477],"tax_institutions":[564],"tax_location_states":[488],"class_list":["post-24685","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Lloyd J. Old STAR","quote":"","scientist_last_name":"Delgoffe","show_on_landing":true,"scientist_publish_until":"20500601"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Greg M. 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