{"id":24622,"date":"2022-09-19T20:17:22","date_gmt":"2022-09-20T00:17:22","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=24622"},"modified":"2025-12-15T15:37:55","modified_gmt":"2025-12-15T20:37:55","slug":"alexander-marson-md-phd","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/alexander-marson-md-phd","title":{"rendered":"Alexander Marson, MD, PhD"},"content":{"rendered":"\n<p>As an inaugural&nbsp;<a href=\"https:\/\/www.cancerresearch.org\/lloyd-j-old-star-program\">CRI Lloyd J. Old STAR<\/a>, Dr. Alexander Marson is using sophisticated CRISPR-based genome editing tools to discover genetic programs that could then be \u201cinstalled\u201d into T cells in order to improve their ability to recognize cancer cells and eliminating tumors.<\/p>\n\n\n\n<p>Human T cells are the main \u201csoliders\u201d of the immune system, and immunotherapies that target or utilize T cells\u2014such as&nbsp;<a href=\"https:\/\/www.cancerresearch.org\/treatment-types\/immunomodulators\">checkpoint inhibitors<\/a>&nbsp;and&nbsp;<a href=\"https:\/\/www.cancerresearch.org\/treatment-types\/adoptive-cell-therapy\">adoptive T cell therapies<\/a>\u2014are revolutionizing cancer treatments, achieving durable responses in many patients with otherwise untreatable disease. However, despite dramatic benefits in some patients, most do not respond to current immunotherapies. Therefore, the goal of Dr. Marson\u2019s research is to discover new critical gene programs in human T cells that can be targeted for novel cancer immunotherapies. To that end, Marson\u2019s lab is pioneering new CRISPR gene editing technologies that offer faster, cheaper, and more precise ways to re-write DNA programs in human immune cells. They have already developed a non-viral CRISPR technology that allows them to \u201ccut\u201d and \u201cpaste\u201d large DNA sequences in human immune cells to program next-generation genetically engineered T cell therapies. Now, they are systematically working to discover genetic \u201cprograms\u201d that we can code into T cell genomes to make the cells more effective at recognizing cancer cells, overcoming immunosuppression in the tumor micro-environment, and eliminating tumors. They will develop synthetic programs that we can write into T cell genomes with CRISPR to boost their capacity to treat cancer.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.cancerresearch.org\/blog\/november-2019\/alexander-marson-star-scientist-t-cell-engineer\">READ OUR INTERVIEW WITH DR. ALEXANDER MARSON<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"562\" src=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2022\/06\/30_Outlooks_Marson.jpg\" alt=\"I'm making a future where next-generation cell therapiescan tackle cancers that are currently incurable. -Dr. Alexander Marson, CRI Scientist\" class=\"wp-image-9581\" srcset=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2022\/06\/30_Outlooks_Marson.jpg 1000w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2022\/06\/30_Outlooks_Marson-300x169.jpg 300w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2022\/06\/30_Outlooks_Marson-768x432.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Reprogramming human immune cells with CRISPR for cancer immunotherapy<\/h3>\n\n\n\n<p>University of California, San Francisco | All Cancers | 2019<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Publications<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Obesity alters pathology and treatment response in inflammatory disease<\/h3>\n\n\n\n<p>Sagar P. Bapat et al | Nature | 2022 |&nbsp;<a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1038\/s41586-022-04536-0\">DOI<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>As an inaugural&nbsp;CRI Lloyd J. Old STAR, Dr. Alexander Marson is using sophisticated CRISPR-based genome editing tools to discover genetic programs that could then be \u201cinstalled\u201d into T cells in order to [&hellip;]<\/p>\n","protected":false},"featured_media":291,"template":"","tax_cancer_type":[455],"tax_grant_type":[482],"tax_award_year":[476],"tax_institutions":[500],"tax_location_states":[501],"class_list":["post-24622","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Lloyd J. 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