{"id":24466,"date":"2022-09-19T20:16:49","date_gmt":"2022-09-20T00:16:49","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_scientists&#038;p=24466"},"modified":"2025-12-15T15:53:10","modified_gmt":"2025-12-15T20:53:10","slug":"joshua-brody","status":"publish","type":"cri_scientists","link":"https:\/\/www.cancerresearch.org\/es\/cri-funded-scientists\/joshua-brody","title":{"rendered":"Joshua D. Brody, MD"},"content":{"rendered":"\n<p>As a CRI Lloyd J. Old STAR, Dr. Brody is investigating a therapeutic\u00a0cancer vaccine\u00a0approach\u2014known as in situ vaccination, or ISV\u2014that induces anti-tumor immunity at the tumor site and can also cause regression of tumors throughout the body.<\/p>\n\n\n\n<p>In animal models, Dr. Brody has observed that ISV made\u00a0PD-1 checkpoint immunotherapy\u2014which was normally ineffective in this context\u2014much more beneficial, leading to cures in 75% of cases. Subsequently, he initiated a new trial combining ISV with PD-1 immunotherapy for lymphoma, breast, or head and neck cancer patients. The first patient treated has already shown tumor regression. However, even when ISV successfully elicits an anti-cancer immune response, sometimes tumors can escape by \u2018losing\u2019 the markers, or antigens, that the immune system was targeting. Fortunately, Dr. Brody has discovered that the Fas gene can make tumor cells sensitive to immune cell killing even if they\u2019ve lost the target antigen, as long as they are near cells that express it.\u00a0<\/p>\n\n\n\n<p>Overall, Dr. Brody\u2019s work will focus on two goals: to characterize and hopefully improve ISV\u2019s anti-tumor immune activity and to further potentiate Fas-mediated bystander killing of cancer cells to prevent antigen escape.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Projects and Grants<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Cross-Priming Anti-Tumor T Cells with In Situ Vaccination and Potentiating Bystander Killing<\/h3>\n\n\n\n<p>Icahn School of Medicine at Mount Sinai | Breast Cancer, Head and Neck Cancer, Leukemia, Lymphoma | 2020<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Flt3L-primed in situ vaccination for low-grade lymphoma<\/h3>\n\n\n\n<p>Icahn School of Medicine at Mount Sinai | Breast Cancer, Lymphoma, Melanoma, Prostate Cancer | 2015<\/p>\n","protected":false},"excerpt":{"rendered":"<p>As a CRI Lloyd J. Old STAR, Dr. Brody is investigating a therapeutic\u00a0cancer vaccine\u00a0approach\u2014known as in situ vaccination, or ISV\u2014that induces anti-tumor immunity at the tumor site and can also cause regression [&hellip;]<\/p>\n","protected":false},"featured_media":5250,"template":"","tax_cancer_type":[365,360,358,355],"tax_grant_type":[482],"tax_award_year":[477],"tax_institutions":[540],"tax_location_states":[494],"class_list":["post-24466","cri_scientists","type-cri_scientists","status-publish","has-post-thumbnail","hentry"],"acf":{"scientist_subhead":"CRI Lloyd J. Old STAR","quote":"","scientist_last_name":"Brody","show_on_landing":true,"scientist_publish_until":"20500601"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Joshua D. 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