{"id":35421,"date":"2025-06-13T11:09:23","date_gmt":"2025-06-13T15:09:23","guid":{"rendered":"https:\/\/www.cancerresearch.org\/?post_type=cri_news&#038;p=35421"},"modified":"2025-06-13T11:09:27","modified_gmt":"2025-06-13T15:09:27","slug":"2025-stars","status":"publish","type":"cri_news","link":"https:\/\/www.cancerresearch.org\/es\/media-room\/2025-stars","title":{"rendered":"CRI Announces 2025 Lloyd J. Old STARs: Five Bold Innovators Driving the Future of Cancer Immunotherapy"},"content":{"rendered":"\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio is-style-rounded\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"CRI Announces 2025 Lloyd J. Old STARs: 5 Bold Innovators Driving the Future of Cancer Immunotherapy\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/zG804KUOgrQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p><em>New York, NY<\/em> \u2014 The Cancer Research Institute (CRI) proudly announces the 2025 class of <a href=\"https:\/\/www.cancerresearch.org\/lloyd-j-old-star-program\">Lloyd J. Old STARs<\/a>\u2014five rising scientific leaders poised to reshape cancer immunotherapy through daring, paradigm-shifting research. Each awardee receives $1.25 million in unrestricted funding over five years, empowering them to pursue high-risk, high-reward projects that could redefine cancer treatment.<\/p>\n\n\n\n<p>\u201cThese are people who are hitting their stride scientifically and career wise, and this is where you really want to put some jet fuel in the tank as they\u2019re getting established,\u201d said Dr. E. John Wherry, Associate Director of CRI\u2019s Scientific Advisory Council. Echoing this sentiment, Dr. Elizabeth Jaffee, also an Associate Director, emphasized, \u201cWe\u2019re picking people who are really our next leaders in the field of immunotherapy.\u201d<\/p>\n\n\n\n<p>CRI\u2019s CEO, Dr. Alicia Zhou, added, \u201cEach of these researchers brings fearless curiosity and a willingness to challenge assumptions \u2014 the very qualities that drive breakthroughs. They aren\u2019t just advancing cancer science; they\u2019re reinventing it.\u201d<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile has-grey-2-color has-medium-purple-background-color has-text-color has-background has-link-color wp-elements-1898ba0985a627183fb59a256463ffca\" style=\"border-width:20px;padding-top:0;padding-bottom:0\"><div class=\"wp-block-media-text__content\">\n<h6 class=\"wp-block-heading has-black-color has-text-color has-link-color wp-elements-267adb72c712b40a972174a93437bad9\">Meet the 2025 Class of Lloyd J. Old STARs\u2014five bold scientists pushing the boundaries of cancer immunotherapy through high-risk, high-reward research. Backed by $1.25 million in flexible funding, these trailblazers are reimagining what\u2019s possible in the fight against cancer. Discover how their fearless ideas are reshaping the future of treatment.<\/h6>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/CRI_STARS-Awards_Fall-25_Digital.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Download Now<\/a><\/div>\n<\/div>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"791\" height=\"1024\" src=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/STARsthumb-791x1024.png\" alt=\"\" class=\"wp-image-35422 size-full\" srcset=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/STARsthumb-791x1024.png 791w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/STARsthumb-232x300.png 232w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/STARsthumb-768x994.png 768w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/STARsthumb-1187x1536.png 1187w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/STARsthumb-1583x2048.png 1583w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/STARsthumb-scaled.png 1978w\" sizes=\"auto, (max-width: 791px) 100vw, 791px\" \/><\/figure><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h1 class=\"wp-block-heading\"><strong>Meet the 2025 Lloyd J. Old STARs<\/strong><\/h1>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/judith-agudo-800x800-1.webp\" alt=\"Judith Agudo\" class=\"wp-image-35413 size-full\" srcset=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/judith-agudo-800x800-1.webp 800w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/judith-agudo-800x800-1-300x300.webp 300w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/judith-agudo-800x800-1-150x150.webp 150w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/judith-agudo-800x800-1-768x768.webp 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p><strong><a href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/judith-agudo-phd\">Judith Agudo, PhD<\/a><\/strong><\/p>\n\n\n\n<p><strong>Principal Investigator, Dana-Farber Cancer Institute<\/strong><\/p>\n\n\n\n<p><strong>Associate Professor of Immunology, Harvard Medical School<\/strong><\/p>\n\n\n\n<p>\u201cIt\u2019s incredibly meaningful. To be recognized alongside pioneers I admire tells me our work matters,\u201d reflected Dr. Agudo. Her lab investigates how cancer cells morph to escape immune attack, developing sophisticated models that mimic real patient biology. This funding enables her team to pursue creative, high-risk experiments faster, advancing an understanding that is critical to more effective therapies.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile\"><div class=\"wp-block-media-text__content\">\n<p><strong><a href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/edward-chuong-phd\">Edward Chuong, PhD\u00a0<\/a><\/strong><\/p>\n\n\n\n<p><strong>Assistant Professor of Molecular, Cellular and Developmental Biology<\/strong><\/p>\n\n\n\n<p><strong>BioFrontiers Institute at University of Colorado Boulder<\/strong><\/p>\n\n\n\n<p>\u201cAs someone from an evolutionary biology background, this award means my outsider ideas are being welcomed into the cancer research community. It\u2019s a huge boost,\u201d said Dr. Chuong. His groundbreaking work focuses on the role that ancient viral fragments in our DNA\u2014called transposons\u2014play in regulating immune cell signaling. Supported by the STAR award, his team is diving into ambitious mouse studies and conducting single-cell sequencing to uncover these hidden mechanisms, aiming to open new therapeutic avenues.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/edward-chuong-800x800-1.webp\" alt=\"Edward Chuong\" class=\"wp-image-35415 size-full\" srcset=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/edward-chuong-800x800-1.webp 800w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/edward-chuong-800x800-1-300x300.webp 300w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/edward-chuong-800x800-1-150x150.webp 150w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/edward-chuong-800x800-1-768x768.webp 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure><\/div>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/ryan-flynn-800x800-1.webp\" alt=\"Ryan Flynn\" class=\"wp-image-35411 size-full\" srcset=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/ryan-flynn-800x800-1.webp 800w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/ryan-flynn-800x800-1-300x300.webp 300w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/ryan-flynn-800x800-1-150x150.webp 150w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/ryan-flynn-800x800-1-768x768.webp 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p><strong><a href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/ryan-flynn-md-phd\">Ryan Flynn, MD, PhD<\/a><\/strong><\/p>\n\n\n\n<p><strong>Principal Investigator, Stem Cell Program, Boston Children\u2019s Hospital<\/strong><\/p>\n\n\n\n<p><strong>Assistant Professor of Stem Cell and Regenerative Biology, Harvard University<\/strong><\/p>\n\n\n\n<p>\u201cThis award, at this level of funding for five years, is really important. It gives us the opportunity to have bold ideas, and there&#8217;s enough runway to actually accomplish it,\u201d said Dr. Flynn. His research explores how RNA-protein complexes outside cells influence immune interactions\u2014a surprising frontier. The STAR award will fuel bold projects like building a modular protein degradation system and using CRISPR tools to unlock new therapeutic strategies.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile\"><div class=\"wp-block-media-text__content\">\n<p><a href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/anusha-kalbasi-md\"><strong>Anusha Kalbasi, MD<\/strong>\u00a0<\/a><\/p>\n\n\n\n<p><strong>Associate Professor of Radiation Oncology, Stanford University School of Medicine<\/strong><\/p>\n\n\n\n<p>\u201cIt\u2019s humbling. To be part of this class feels like a milestone in my journey,\u201d shared Dr. Kalbasi. His lab studies how cytokines influence T cell behavior and function. Using high-throughput screens and new computational tools, his team aims to design smarter immunotherapies for patients with sarcoma and other solid tumors.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/anusha-kalbasi.webp\" alt=\"Anusha Kalbasi\" class=\"wp-image-35417 size-full\" srcset=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/anusha-kalbasi.webp 800w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/anusha-kalbasi-300x300.webp 300w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/anusha-kalbasi-150x150.webp 150w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/anusha-kalbasi-768x768.webp 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure><\/div>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/wu-tuoqi-800x800-1.webp\" alt=\"Tuoqi Wu\" class=\"wp-image-35409 size-full\" srcset=\"https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/wu-tuoqi-800x800-1.webp 800w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/wu-tuoqi-800x800-1-300x300.webp 300w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/wu-tuoqi-800x800-1-150x150.webp 150w, https:\/\/www.cancerresearch.org\/wp-content\/uploads\/2025\/06\/wu-tuoqi-800x800-1-768x768.webp 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p><strong><a href=\"https:\/\/www.cancerresearch.org\/cri-funded-scientists\/tuoqi-wu-phd\">Tuoqi Wu, PhD<\/a><\/strong><\/p>\n\n\n\n<p><strong>Assistant Professor of Immunology, The University of Texas Southwestern Medical Center<\/strong><\/p>\n\n\n\n<p>\u201cThis award confirms that our ideas are on the right track\u2014and gives us momentum,\u201d said Dr. Wu, who is engineering smarter CAR T cells with chemical \u201cswitches\u201d to overcome exhaustion and improve efficacy against solid tumors. In the coming year, his group will focus on reprogramming T cells to reverse exhaustion, laying the groundwork for next-generation immunotherapies.<\/p>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><strong>The Lloyd J. Old STAR program<\/strong> honors CRI\u2019s founding scientific and medical director, recognizing scientists who embody the pioneering spirit fueling immunotherapy\u2019s progress. As Dr. Kunle Odunsi, Associate Director of CRI\u2019s Scientific Advisory Council, notes, these awards provide \u201cthe freedom and resources needed to ask paradigm-shifting questions that move the field forward.\u201d<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>New York, NY \u2014 The Cancer Research Institute (CRI) proudly announces the 2025 class of Lloyd J. Old STARs\u2014five rising scientific leaders poised to reshape cancer immunotherapy through daring, paradigm-shifting research. Each [&hellip;]<\/p>\n","protected":false},"featured_media":35431,"template":"","tags":[],"resource_cancer_types":[],"resource_patient_age":[],"resource_cancer_stage":[],"resource_treatment_type":[],"resource_treatment_status":[],"class_list":["post-35421","cri_news","type-cri_news","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CRI Announces 2025 Lloyd J. Old STARs: Five Bold Innovators Driving the Future of Cancer Immunotherapy - Cancer Research Institute<\/title>\n<meta name=\"description\" content=\"The Cancer Research Institute (CRI) proudly announces the 2025 class of Lloyd J. Old STARs\u2014five rising scientific leaders poised to reshape cancer immunotherapy through daring, paradigm-shifting research. 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