{"id":11225,"date":"2018-07-11T00:00:00","date_gmt":"2018-07-11T00:00:00","guid":{"rendered":"https:\/\/www.cancerresearch.org\/media-room\/ludwig-cancer-research-and-cancer-research-institute-launch-clinical-trial-combining-virotherapy-and-immunotherapy-to-treat-advanced-colorectal-and-ovarian-cancers\/"},"modified":"2024-10-31T10:22:22","modified_gmt":"2024-10-31T14:22:22","slug":"ludwig-cri-trial-virotherapy-immunotherapy","status":"publish","type":"cri_news","link":"https:\/\/www.cancerresearch.org\/es\/media-room\/ludwig-cri-trial-virotherapy-immunotherapy","title":{"rendered":"Ludwig Cancer Research and Cancer Research Institute Launch Clinical Trial Combining Virotherapy and Immunotherapy to Treat Advanced Colorectal and Ovarian Cancers"},"content":{"rendered":"\n

Ludwig Cancer Research and the Cancer Research Institute (CRI) announce the initiation of a clinical trial to evaluate the combination of ONCOS-102, an experimental anti-tumor virotherapy, with the checkpoint blockade antibody IMFINZI\u00ae (durvalumab) for advanced ovarian and colorectal cancers. <\/p>\n\n\n\n

The Phase I\/II trial, which has completed enrollment and the safety evaluation for the first patient cohort, could ultimately enroll as many as 78 adult patients in a multi-center program at leading academic centers, including Memorial Sloan Kettering Cancer Center (MSK), the Roswell Park Comprehensive Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami (UM\/Sylvester) and the University of Virginia Health System (UVA). It is chaired by Ludwig and CRI investigator Dmitriy Zamarin of MSK. Kunle Odunsi of Roswell Park and Brian Slomovitz of UM\/Sylvester are overseeing the trial at their respective institutions with locations to be added for the new cohorts. MedImmune, the global biologics research and development arm of AstraZeneca that developed durvalumab, and Targovax, the biopharmaceutical company that developed ONCOS-102, are also collaborators in the clinical trial.<\/p>\n\n\n\n

\u201cPatients diagnosed with advanced ovarian and colorectal cancers that have progressed on standard therapies have very few treatment options available to them,\u201d said Vanessa Lucey, director of the CRI Venture Fund and Clinical Accelerator. \u201cUnder a unique partnership model, this study leverages the capabilities of two prominent nonprofit groups, accelerates innovation with top academic centers, and includes two different bio-pharmaceutical companies. This is the type of coordination and collaboration we need to accelerate progress for patients.\u201d  <\/p>\n\n\n\n

\u201cAlthough checkpoint blockade antibodies have been remarkably effective in treating a variety of cancers, many patients fail to respond to these immunotherapies,\u201d said Jonathan Skipper, Ludwig\u2019s executive vice president for technology development. \u201cEliciting therapeutic responses in such patients through combination therapies is a top priority of Ludwig\u2019s clinical research program, and a major objective of CRI\u2019s as well. We have good reason to believe that combining checkpoint blockade with oncolytic virotherapy is a highly promising strategy to that end. We very much look forward to seeing the results of this trial.\u201d<\/p>\n\n\n\n

ONCOS-102 is a serotype 5 adenovirus\u2014a relative of the cold virus\u2014that has been engineered to selectively infect and kill cancer cells. The virus has also been modified to express a gene for an immune factor known as granulocyte-macrophage colony stimulating factor (GM-CSF), which boosts critical elements of the immune response. ONCOS-102 has been shown in a previous trial to be safe and to induce anti-cancer immune responses. <\/p>\n\n\n\n

Durvalumab, which is already approved for clinical use in other cancers, is a human monoclonal antibody directed against PD-L1. PD-L1 ordinarily protects healthy cells from destruction by a runaway immune response. Tumor cells, however, can co-opt PD-L1 to evade attack by the immune system\u2019s killer T cells. Durvalumab blocks PD-L1 interaction with PD-1 and CD80, countering the tumor’s immune-evading tactics and inducing an immune response. <\/p>\n\n\n\n

There is emerging evidence that combining checkpoint blockade with virotherapy could have a therapeutic effect against cancers. Viral infection of cancer cells is hypothesized to draw activated killer T cells into tumors. Once in the tumor, the T cells are exposed to telltale antigens released by dying cancer cells, potentially awakening an immune response against the malignancy as well. <\/p>\n\n\n\n

Preclinical research<\/a> done on mice by Zamarin and others has shown that infecting a tumor with an oncolytic virus and following up with a checkpoint blockade therapy elicits a systemic immune response that targets not only the infected tumor but also other tumors in the body. It is hoped that the GM-CSF expressed by the virus as it multiplies in cancer cells will further boost this kind of anti-tumor response.<\/p>\n\n\n\n

The current trial is enrolling patients whose colorectal or ovarian cancers have become resistant to all conventional treatment and whose tumors have spread into the peritoneum\u2014the membrane around the abdominal cavity. ONCOS-102 is being delivered directly into the peritoneal membrane, while durvalumab will be given systemically. <\/p>\n\n\n\n

The objectives of this open label trial are to test the safety and preliminary efficacy of the combination, optimize dosing, evaluate the feasibility of peritoneal delivery of ONCOS-102 and inform current and future translational research.\u00a0<\/p>\n\n\n\n\n\n

About Ludwig Cancer Research<\/strong><\/p>\n\n\n\n

Ludwig Cancer Research is an international collaborative network of acclaimed scientists that has pioneered cancer research and landmark discovery for more than 40 years. Ludwig combines basic science with the ability to translate its discoveries and conduct clinical trials to accelerate the development of new cancer diagnostics and therapies. Since 1971, Ludwig has invested $2.7 billion in life-changing science through the not-for-profit Ludwig Institute for Cancer Research and the six U.S.-based Ludwig Centers. To learn more, visit www.ludwigcancerresearch.org<\/a>.<\/p>\n\n\n\n

For further information please contact Rachel Reinhardt, rreinhardt@lcr.org<\/a> or +1-212-450-1582.<\/p>\n\n\n\n

About the Cancer Research Institute<\/strong><\/p>\n\n\n\n

The Cancer Research Institute (CRI), established in 1953, is the world\u2019s leading nonprofit organization dedicated exclusively to immuno-oncology, also called cancer immunotherapy. CRI has invested over $384 million to support research conducted by a global network of immunologists and clinical experts at the world\u2019s leading medical centers and universities. CRI\u2019s clinical program, The Anna-Maria Kellen Clinical Accelerator, is a unique academia-industry collaboration model that serves as an \u201cincubator\u201d for promising new immunotherapy combinations. CRI\u2019s venture philanthropy fund supports clinical trials within this program, which fosters a collaborative environment that enables scientists to advance their most ambitious clinical and translational research ideas, and accelerates studies that one group or company could not do alone. To learn more, go to www.cancerresearch.org<\/a>.<\/p>\n\n\n\n

For further information please contact Brian Brewer, bbrewer@cancerresearch.org<\/a> or +1-212-688-7515 x242.<\/p>\n","protected":false},"excerpt":{"rendered":"

Ludwig Cancer Research and the Cancer Research Institute (CRI) announce the initiation of a clinical trial to evaluate the combination of ONCOS-102, an experimental anti-tumor virotherapy, with the checkpoint blockade antibody IMFINZI® (durvalumab) for advanced ovarian and colorectal cancers. <\/p>\n","protected":false},"featured_media":2694,"template":"","tags":[30],"resource_cancer_types":[],"resource_patient_age":[],"resource_cancer_stage":[],"resource_treatment_type":[],"resource_treatment_status":[],"class_list":["post-11225","cri_news","type-cri_news","status-publish","has-post-thumbnail","hentry","tag-clinical-accelerator"],"acf":[],"yoast_head":"\nLudwig Cancer Research and Cancer Research Institute Launch Clinical Trial Combining Virotherapy and Immunotherapy to Treat Advanced Colorectal and Ovarian Cancers - Cancer Research Institute<\/title>\n<meta name=\"description\" content=\"Ludwig Cancer Research and CRI launch a groundbreaking trial combining virotherapy and immunotherapy for colorectal and ovarian cancers.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cancerresearch.org\/media-room\/ludwig-cri-trial-virotherapy-immunotherapy\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ludwig Cancer Research and Cancer Research Institute Launch Clinical Trial Combining Virotherapy and Immunotherapy to Treat Advanced Colorectal and Ovarian Cancers - 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